Partial remission by cyclosporine monotherapy in a patient with membranous nephropathy superimposed diabetic nephropathy

CEN Case Reports
Yoshiyuki OshiroNiro Okimoto

Abstract

It has been noted that cyclosporine A (CsA) is an effective drug for membranous nephropathy (MN). Diabetes is a common disease that sometimes causes nephrotic syndrome. We report the case of an 89-year-old woman with type 2 diabetes mellitus who exhibited nephrotic syndrome. Examination of a renal biopsy indicated MN and she was prescribed CsA as monotherapy. Her edema subsided and she achieved partial remission. This is the first report of a patient in diabetic condition with MN having achieved partial remission after CsA monotherapy without steroid therapy. The use of steroid in patients with diabetes may worsen their diabetic condition, especially if they are of very advanced age. CsA monotherapy may be useful for diabetic patients with MN.

References

Jun 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S L HoganR J Falk
Apr 17, 2004·Kidney International·Hideo ShiikiUNKNOWN Research Group on Progressive Renal Diseases in Japan
Sep 14, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Efstathios AlexopoulosDimitrios Memmos
May 15, 2007·American Journal of Nephrology·Tam T PhamVictoria A Kumar
Jan 30, 2010·Journal of the American Society of Nephrology : JASN·Natalia PolancoUNKNOWN Grupo de Estudio de las Enfermedades Glomerulares de la Sociedad Española de Nefrología
Jul 23, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Laurence BeckMeryl Waldman

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