PMID: 2507792Nov 1, 1989Paper

Partial reversion of conditional transformation correlates with a decrease in the sensitivity of rat cells to killing by the parvovirus minute virus of mice but not in their capacity for virus production: effect of a temperature-sensitive v-src oncogene

Journal of Virology
N SaloméJ Rommelaere

Abstract

The cytolytic effect of the autonomous parvovirus minute virus of mice, prototype strain (MVMp), was studied in cultures of ts 339/NRK rat cells that display a temperature-sensitive transformed phenotype as a result of their transformation with a Rous sarcoma virus strain matured in the v-src oncogene. A shift from restrictive (39.5 degrees C) to permissive (34.5 degrees C) temperature was associated with a marked sensitization of these cells to killing by MVMp. In contrast, ts 339/NRK cell derivatives supertransformed with a wild-type src oncogene were sensitive to MVMp at both temperatures, suggesting that the expression of a functional oncogene product may determine, at least in part, the extent of the parvoviral cytopathic effect. Although ts 339/NRK cells were quite resistant to parvoviral attack at 39.5 degrees C, they were similarly proficient in MVMp uptake, viral DNA and protein synthesis, and infectious particle production at both permissive and restrictive temperatures. Consistently, electron microscopic examination of infected ts 339/NRK cultures incubated at 39.5 degrees C revealed the presence, in the majority of the cells, of numerous full and empty virions that were predominantly located in autophagic-type vacuo...Continue Reading

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Citations

May 21, 2005·Chinese Journal of Digestive Diseases·Jiong LiuJean Rommelaere
Jul 1, 2020·Annual Review of Virology·Anna HartleyAntonio Marchini
Aug 16, 2008·PLoS Pathogens·Séverine BärJürg P F Nüesch
May 9, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jürg P F NüeschJean Rommelaere
Mar 1, 1994·Mutation Research·J R Schlehofer

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