Partial role of 5-HT2 and 5-HT3 receptors in the activity of antidepressants in the mouse forced swimming test

European Journal of Pharmacology
J P Redrobe, M Bourin

Abstract

The present study was designed to evaluate the roles of 5-HT2 and 5-HT3 receptors in the mouse forced swimming test, by using selective agonists and antagonists of 5-HT(2A/C) and 5-HT3 receptor sites. Agonists/antagonists and antidepressants were administered 45 min and 30 min, respectively, prior to testing. Pretreatment with (+/-)-2,5-dimethoxy-4-iodoamphetamine (DOI) (4 mg/kg, i.p.) or 2-methyl-5-HT (4 mg/kg, i.p.) had no effect on the anti-immobility effects of any antidepressant tested. Prior administration of ritanserin (4 mg/kg, i.p.) or ketanserin (8 mg/kg, i.p.), on the other hand, potentiated the effects of sub-active doses of imipramine (8 mg/kg, i.p.) and desipramine (16 mg/kg, i.p.) but not of maprotiline (8 mg/kg, i.p.), fluoxetine (16 mg/kg, i.p.), citalopram (16 mg/kg, i.p.) or fluvoxamine (8 mg/kg, i.p.). Pretreatment with ondansetron (1 X 10(-5) mg/kg, i.p.) enhanced the antidepressant-like effects of sub-active doses of the selective serotonin reuptake inhibitors. The results of the present study suggested that, in the forced swimming test, the selective serotonin reuptake inhibitors act partially through 5-HT3 receptor sites, whereas the tricyclic antidepressants exert effects at 5-HT(2A/C) receptor sites. A...Continue Reading

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Citations

Jun 22, 2006·Psychopharmacology·Naoko BekkuHiroaki Araki
Nov 26, 2010·Psychopharmacology·Gregory V Carr, Irwin Lucki
Mar 19, 2013·Behavioural Brain Research·Amber LockridgeLi-Lian Yuan
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Apr 21, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·F ClenetM Bourin
Mar 2, 2002·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jean-Philippe RénéricLuis Stinus
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Jun 14, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alison A WilliamsAmelia L Gallitano
May 12, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gerard J MarekFrancesc Artigas
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