Partial sciatic nerve transection causes redistribution of pain-related peptides and lowers withdrawal threshold

Experimental Neurology
Muthulekha SwamydasJoshua E Adler

Abstract

Complete nerve transection results in loss of sensation and paralysis of the involved extremity. Such injury drastically reduces content of the nociceptive peptides, substance P, and somatostatin in the dorsal horn of the spinal cord and dorsal root ganglia innervating the limb. Partial nerve injuries occur more commonly in clinical practice, however, and frequently result in the development of chronic neuropathic pain. To investigate mechanisms underlying this pathologic pain syndrome, rats were subjected to partial sciatic nerve transection. Withdrawal thresholds determined with Von Frey hairs dropped dramatically in the operated limb. On postoperative Day 4, thresholds had decreased from 15 g to less than 5 g on the operated side, whereas those on the contralateral (unoperated) side or those from sham-operated rats did not change. Sciatic hemisection had no effect on total content of either substance P or somatostatin in the dorsal spinal cord and lumbar dorsal root ganglia as measured by radioimmunoassay on postoperative Days 4, 7, or 14. However, when examined immunohistochemically, there was a marked redistribution of both peptides associated with partial transection. On the contralateral side or in sham-operated rats, bo...Continue Reading

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Citations

Dec 19, 2012·The Spine Journal : Official Journal of the North American Spine Society·Changsheng HuangQulian Guo
Apr 4, 2009·Experimental Neurology·Anne M SkoffJoshua E Adler
Oct 26, 2007·Pharmacology & Therapeutics·Hui-Lin PanDe-Pei Li
Jul 24, 2007·Progress in Neurobiology·X NavarroAntoni Valero-Cabré
Mar 15, 2006·Gastroenterology Clinics of North America·Michael D Adolph, Costantino Benedetti
Oct 28, 2010·British Journal of Pharmacology·T M Largent-MilnesT W Vanderah
May 9, 2006·The Journal of Comparative Neurology·Wendy WeissnerGeoffrey M Bove
Nov 27, 2007·Journal of Tissue Engineering and Regenerative Medicine·Minal PatelPamela J Vandevord
May 12, 2010·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Donna J MillingtonJason Obirek

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