Partial selectivity of 6-OHDA induced neuronal degeneration after intraissular injection in the brain with special reference to the nigro-striatal dopamine system.

Journal of Neural Transmission
F Javoy

Abstract

The selectivity of 6-OHDA induced neuronal degeneration after intra-tissular injection in the brain is discussed considering the morphological and biochemical events occurring in the substantia nigra and in the striatum--after intranigral or intrastriatal application of the drug. The data suggest that a critical intratissular concentration of 6-OHDA is required to induce an elective neuronal degeneration. The importance of the non-specific damage can not be neglected when high doses of the drug are administered in the brain tissue.

References

Jan 1, 1968·Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie·H Thoenen, J P Tranzer
May 1, 1972·European Journal of Pharmacology·B R JacksJ P Cordeau
Feb 1, 1970·Journal of Neurochemistry·N J Uretsky, L L Iversen
Apr 1, 1968·European Journal of Pharmacology·T Malmfors, C Sachs
Dec 1, 1968·European Journal of Pharmacology·U Ungerstedt

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Citations

Sep 1, 1977·Pharmacology, Biochemistry, and Behavior·D C Roberts, H C Fibiger
Jun 1, 1985·Brain Research·G L Willis, G C Smith
Jun 1, 1986·Journal of Neurology·P VogelF J Schmidt

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