Partial synthesis and biological evaluation of bisbenzylisoquinoline alkaloids derivatives: potential modulators of multidrug resistance in cancer

Journal of Asian Natural Products Research
Ping HeFeng-Peng Wang

Abstract

A series of new bisbenzylisoquinoline alkaloids was partially synthesized from tetrandrine and fangchinoline and evaluated for their ability to reverse P-glycoprotein-mediated multidrug resistance (MDR) in cancer cells. All the test compounds increased the intracellular accumulation rate of rhodamine 123 in MDR cells (Bel7402 and HCT8), and most exhibited more potent MDR-reversing activity relative to the reference compound verapamil. Compounds 8, 10, 13, and 14 enhanced intracellular accumulation of doxorubicin in Bel7402 and HCT8 cells.

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Citations

Jun 1, 2016·Journal of Asian Natural Products Research·Xiao WeiYue-Wei Guo
Jun 2, 2018·Journal of Asian Natural Products Research·Qian-Hao YangZheng-Bao Zhao
Aug 16, 2013·Journal of Asian Natural Products Research·Chun-Zhen WuYi-Fang Yang

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