Partially absorbable mesh or native tissue repair for pelvic organ prolapse: a randomized controlled trial

International Urogynecology Journal
Pieternel SteuresMariella I J Withagen

Abstract

The objective was to compare medium-term efficacy and safety of a partially absorbable mesh kit and native tissue repair in pelvic organ prolapse (POP). Women with primary POP stage ≥ II were randomized to transvaginal trocar-guided partially absorbable mesh (81 women) or native tissue repair (82 women). Primary outcome was overall anatomical success (POP < stage II) at 24 months. Secondary outcomes were composite success, global improvement, and adverse events. Sixty-nine (85%) of the women allocated to partially absorbable mesh underwent mesh surgery; 8 (10%) crossed over to native tissue repair and 4 women (5%) withdrew from the study. Eighty (98%) of the women allocated to native tissue repair underwent the assigned treatment and 2 (2%) withdrew. Twenty-four months later, 140 surgically treated women (89%) demonstrated an overall anatomical success of 39%; 45% (32 out of 71 women) for mesh, and 32% (22 out of 69) for native tissue repair (RR 1.4, 95% CI 0.92 to 2.2). Composite success was 88 and 73% respectively (RR: 1.1, 95% CI 0.93 to 1.4). There was global improvement in 86% (48 out of 56 women) in the mesh group and in 77% (47 out of 60 women) in the native tissue group (RR: 1.1, 95% CI 0.92 to 1.3). Four women were dia...Continue Reading

References

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Citations

May 23, 2020·International Urology and Nephrology·José Tadeu Nunes TamaniniManoel João Batista Castello Girão
Jan 29, 2020·International Urogynecology Journal·Themos GrigoriadisDiaa Rizk
Aug 22, 2021·Obstetrics and Gynecology Clinics of North America·Visha TailorSteven Edward Swift
Jun 5, 2021·American Journal of Obstetrics and Gynecology·Danielle D AntoshRebecca G Rogers
Jan 20, 2022·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Nathalie Ng-StollmannTanja Hüsch

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Methods Mentioned

BETA
hysterectomies
dissection
hysterectomy
amputation

Clinical Trials Mentioned

NCT02231099

Software Mentioned

Prolift

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