Partially Hydrolyzed Whey Infant Formula: Literature Review on Effects on Growth and the Risk of Developing Atopic Dermatitis in Infants from the General Population

International Archives of Allergy and Immunology
Julien SauserCarine Blanchard

Abstract

Limited evidence is available regarding the effect of partially hydrolyzed whey-based formula (pHF-W) on growth and atopic dermatitis (AD) risk reduction in infants within the general infant population, and without a familial history of allergy as an inclusion or exclusion criterion. We reviewed the current evidence available from studies using pHF-W in the general population and summarized the data on safety (growth) and efficacy outcomes (reduction of AD), comparing the studies side by side. A total of 8 clinical trials were identified from the literature search, 7 of which used the same pHF-W. Six out of 8 studies indicated a reduction of atopic manifestations using a specific pHF-W versus cow's milk formula (CMF) in the first years of life. Data were summarized and compared side by side for growth (3 studies) and efficacy (5 studies). In these diverse general populations, the results on growth and AD were consistent with the previous findings reported on infants with a family history of allergy, but numerous limitations to these studies were identified. This literature review confirms that pHF-W supports normal growth in infants, and suggests that the risk of AD may be reduced in not-fully breastfed infants from the general...Continue Reading

Citations

Jan 18, 2019·Korean journal of pediatrics·Yvan VandenplasDeni Krisnamurti
Mar 14, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Anna TokajukHalina Car
Nov 11, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Yvan VandenplasValerie Verhasselt
Nov 7, 2018·International Archives of Allergy and Immunology·Dagmar Simon
Nov 7, 2019·International Archives of Allergy and Immunology·Dagmar Simon

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