Participant-Related Risk Factors for False-Positive and False-Negative Fecal Immunochemical Tests in Colorectal Cancer Screening: Systematic Review and Meta-Analysis

The American Journal of Gastroenterology
Clasine M de KlerkEvelien Dekker

Abstract

Colorectal cancer (CRC) screening using fecal immunochemical tests (FIT) may reduce CRC-related mortality but its effectiveness is influenced by the limited accuracy of FIT. Identifying individuals at increased risk of a false FIT result could improve screening, but the available evidence is conflicting. We performed a systematic review and meta-analysis on risk factors for false-positive and false-negative FIT results in CRC screening. A systematic search in MEDLINE, EMBASE, and Cochrane Library identified publications (before 29 January 2017) on risk factors (known at time of FIT invitation) associated with false FIT results (presence/absence of advanced neoplasia) in a CRC screening setting. Risk of bias was assessed using QUIPS. In meta-analysis, summary relative risk ratios and corresponding 95% confidence intervals were calculated for each risk factor. Of 518 records identified, 14 studies with 54,499 participants in total were included for analysis. In meta-analysis, male sex was associated with a significantly lower risk of false-positivity (RR 0.84, CI 0.74-0.94), whereas participants using non-steroidal anti-inflammatory drugs (NSAIDs) had a higher risk (RR 1.16, CI 1.06-1.27). The use of anticoagulants was most frequ...Continue Reading

References

Jan 11, 2001·International Journal of Colorectal Disease·H NakamaX Zhang
May 2, 2001·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·G HoffI E Moen
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Nov 17, 2005·Journal of the National Cancer Institute·Susanna C LarssonAlicja Wolk
Jul 10, 2007·The American Journal of Gastroenterology·Tamiya MorikawaYasushi Shiratori
May 2, 2009·International Journal of Cancer. Journal International Du Cancer·Leo G M van RossumEvelien Dekker
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Aug 12, 2010·The American Journal of Gastroenterology·Hermann BrennerSabrina Hundt
Dec 9, 2010·JAMA : the Journal of the American Medical Association·Hermann BrennerUlrike Haug
Aug 4, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Tsung-Hsien ChiangMing-Shiang Wu
Oct 19, 2011·Annals of Internal Medicine·Penny F WhitingUNKNOWN QUADAS-2 Group
Nov 24, 2011·The American Journal of Gastroenterology·Aafke H C van RoonMonique E van Leerdam
Mar 13, 2012·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Linda RabeneckNancy Lewis
Apr 5, 2012·Journal of the National Cancer Institute·Callum G FraserUNKNOWN Expert Working Group on Fecal Immunochemical Tests for Hemoglobin, Colorectal Cancer Screening Committee, World Endoscopy Or
Jun 26, 2012·Gastrointestinal Endoscopy·Sietze T van TurenhoutLeo G M van Rossum
Aug 2, 2012·The American Journal of Gastroenterology·T R de WijkersloothE J Kuipers
Feb 5, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Han-Mo ChiuMing-Shiang Wu
Feb 20, 2013·Annals of Internal Medicine·Jill A HaydenClaire Bombardier
May 8, 2013·International Journal of Cancer. Journal International Du Cancer·Inge StegemanPatrick M Bossuyt
Jun 5, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·M J DentersE Dekker
Dec 12, 2013·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Yosuke TsujiKazuhiko Koike
Jan 30, 2014·Gastrointestinal Endoscopy·Li-Chun ChangHan-Mo Chiu
Feb 6, 2014·British Journal of Cancer·L BujandaUNKNOWN COLONPREV study investigators
Mar 25, 2014·Annals of Internal Medicine·Jeffrey K LeeDouglas A Corley
Sep 10, 2014·International Journal of Cancer. Journal International Du Cancer·Sébastien ChausserieLydia Guittet
Mar 1, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Atija KapidzicErnst J Kuipers
Mar 1, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Martin C S WongJoseph J Y Sung
Mar 25, 2015·Gastroenterology Research and Practice·M GarciaV Moreno
Apr 2, 2015·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Vincent DancourtCome Lepage

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Citations

May 3, 2020·International Journal of Colorectal Disease·J A BaileyA Banerjea
Nov 8, 2020·Journal of Gastroenterology·Gemma Ibáñez-SanzVictor Moreno
Oct 20, 2020·Current Opinion in Gastroenterology·Susan Lou, Aasma Shaukat
Sep 4, 2020·Journal of the American Geriatrics Society·Patrick P CollImran Ali
Apr 4, 2021·Cancers·Enea FerlizzaMattia Lauriola
Nov 24, 2019·Gastroenterology·Michael F KaminskiDouglas K Rex
May 14, 2021·International Journal of Colorectal Disease·M J Domper ArnalA Lanas
May 16, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Subashini ChandrapalanRamesh P Arasaradnam
Jun 16, 2021·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Wei-Chun ChengBor-Shyang Sheu

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