Participation in Physical Activity and Risk for Amyotrophic Lateral Sclerosis Mortality Among Postmenopausal Women

JAMA Neurology
Yvonne L EaglehouseLewis H Kuller

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disease with no known cause. Case studies primarily of athletes and several case-control studies have suggested that high levels of strenuous physical activity (PA) may increase the risk for ALS. This relationship has yet to be evaluated among women in population-based cohort studies. To evaluate the relationship between PA and risk for ALS mortality in a large cohort of postmenopausal women. The Women's Health Initiative (WHI) enrolled 161 809 postmenopausal women, aged 50 to 79 years (mean [SD] age, 63.6 [7.24] years), between 1993 and 1998 into either a clinical trial or an observational study at 40 clinical research centers across the United States. We conducted a cohort study from November 2014 to September 2015 using baseline and mortality data during an average of 9.6 years of follow-up from the entire WHI cohort, through September 1, 2013 (with 1.1% lost to follow-up), to address whether there is a relationship between PA and ALS mortality. The WHI assessed frequency and duration of mild, moderate, and strenuous PA at baseline via self-administered questionnaire. Underlying cause of death from ALS collected from death certificates. The WHI enrolled 161 809 wome...Continue Reading

Citations

Mar 10, 2016·European Journal of Epidemiology·Alberto Ascherio, Eilis Joan O'Reilly
May 29, 2016·Progress in Neurobiology·Mónica ZufiríaAdolfo López de Munain
Aug 5, 2016·MMWR. Surveillance Summaries : Morbidity and Mortality Weekly Report. Surveillance Summaries·Paul MehtaKevin Horton
Sep 7, 2016·European Journal of Epidemiology·Lewis H Kuller
Feb 15, 2018·Muscle & Nerve·Doreen T Ho, James A Russell
Apr 17, 2018·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Éilis J O'ReillyStephanie A Smith-Warner
Apr 25, 2018·Journal of Neurology, Neurosurgery, and Psychiatry·Anne E VisserUNKNOWN Euro-MOTOR consortium
Apr 2, 2019·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Pingping NingYanming Xu
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