Participation of 5-HT3, 5-HT4, and nicotinic receptors in the peristaltic reflex of guinea pig distal colon

The American Journal of Physiology
M KadowakiM D Gershon

Abstract

The roles of 5-hydroxytryptamine3 (5-HT3), 5-HT4, and nicotinic receptors in the peristaltic reflex were investigated in isolated segments of guinea pig distal colon. The reflex assessed by measuring the propulsion of solid pellets, was affected neither by 5-HT3-selective antagonists (ondansetron granisetron) nor by 5-HT4-selective antagonists (SDZ-205-557, GR-113808A, SB-204070) applied individually (1.0 microM); nevertheless, the reflex was inhibited by combining these antagonists or by applying a 5-HT3/5-HT4 dual antagonist (FK-1052). Hexamethonium abolished the peristaltic reflex at 100 microM, but not at 10-32 microM. In contrast, the peristaltic reflex was inhibited when hexamethonium (32 microM was combined with either a 5-HT3- or 5-HT4-selective antagonist (1.0 microM). These observations suggest that 5-HT3, 5-HT4, and nicotinic receptors participate in the initiation and/or propagation of the peristaltic reflex. The data are consistent with the idea that these receptors are arranged in parallel in the neural pathways that mediate the peristaltic reflex in the distal colon.

Citations

Apr 19, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Elena Fiorica-HowellsMichael D Gershon
Sep 23, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sushil K Sarna
Mar 10, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·R M Gwynne, J C Bornstein
Feb 9, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Melina EllisJoel C Bornstein
Mar 11, 2020·Nature Reviews. Gastroenterology & Hepatology·Nick J Spencer, Hongzhen Hu
Mar 21, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·David R LindenGary M Mawe
Sep 30, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alan E LomaxKeith A Sharkey
Apr 24, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Eamonn J DicksonTerence K Smith
Apr 3, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sarah Nicholas, Nick J Spencer
Mar 19, 2016·The Journal of Physiology·Nick J SpencerMarcello Costa
Mar 11, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Henry C LinJin Hai Chen
Sep 23, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·L WangY Taché
May 27, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Rumi TanakaMineko Fujimiya
Oct 12, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·T C SiaN J Spencer
Aug 16, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mona LiSushil K Sarna
Jun 28, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Nick J SpencerDamien J Keating
Oct 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Min-Tsai LiuMichael D Gershon
Dec 10, 2008·The Journal of Physiology·Kathleen B NealJoel C Bornstein
Nov 14, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·John R KonenGary M Mawe
Sep 2, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sarah A NajjarKristen M Smith-Edwards

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
H Pan, M D Gershon
© 2021 Meta ULC. All rights reserved