Participation of Arachidonic Acid Metabolism in the Aortic Aneurysm Formation in Patients with Marfan Syndrome

Frontiers in Physiology
María Elena SotoI Pérez-Torres

Abstract

Marfan syndrome (MFS) is a pleiotropic genetic disease involving the cardiovascular system where a fibrillin-1 mutation is present. This mutation is associated with accelerated activation of transforming growth factor β (TGFβ1) which contributes to the formation of aneurysms in the root of the aorta. There is an imbalance in the synthesis of thromboxane A2(TXA2) and prostacyclin, that is a consequence of a differential protein expression of the isoforms of cyclooxygenases (COXs), suggesting an alteration of arachidonic acid (AA) metabolism. The aim of this study was to analyze the participation of AA metabolism associated with inflammatory factors in the dilation and dissection of the aortic aneurysm in patients with MFS. A decrease in AA (p= 0.02), an increase in oleic acid (OA), TGFβ1, tumor necrosis factor alpha (TNFα), prostaglandin E2(PGE2) (p< 0.05), and COXs activity (p= 0.002) was found. The expressions of phospholipase A2(PLA2), cytochrome P450 (CYP450 4A), 5-lipoxygenase (5-LOX), COX2 and TXA2R (p< 0.05) showed a significant increase in the aortic aneurysm of patients with MFS compared to control subjects. COX1, 6-keto-prostaglandin 1 alpha (6-keto-PG1α) and 8-isoprostane did not show significant changes. Histological...Continue Reading

References

Jan 1, 1987·Experimental Lung Research·W M SeligR A Rhoades
Jul 1, 1968·Thorax·H Bentall, A De Bono
Oct 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·V Di Marzo
Sep 16, 1999·Biochemical Pharmacology·R LangenbachH Tiano
May 16, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·P SwartbolL Norgren
Nov 8, 2002·Biochimica Et Biophysica Acta·Joachim Grötzinger
Jan 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Rainer SpanbroekAndreas J R Habenicht
Feb 25, 2003·Nature Genetics·Enid R NeptuneHarry C Dietz
Jan 13, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Florian KrötzUlrich Pohl
Aug 24, 2005·Biochemical and Biophysical Research Communications·Kenneth K Wu, Jun-Yang Liou
Sep 13, 2005·Cell Metabolism·Helene FrancoisThomas M Coffman
Oct 20, 2005·The Journal of Clinical Endocrinology and Metabolism·Luigi FerrucciJack M Guralnik
Dec 2, 2006·Cardiovascular Research·Jonathan M GitlinCharles D Loftin
Jul 7, 2007·Canadian Journal of Physiology and Pharmacology·Jihong JiangJohn H McNeill
Jun 12, 2008·Annual Review of Genomics and Human Genetics·Dianna M MilewiczHariyadarshi Pannu
Dec 2, 2008·Cell Metabolism·Vladimir R BabaevMacrae F Linton
Jun 16, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Yuttana ChawengsubWilliam B Campbell
Jul 21, 2010·Cellular Microbiology·Amanda Linkous, Eugenia Yazlovitskaya
Jan 5, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Kathryn M GauthierWilliam B Campbell
Apr 22, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Emanuela Ricciotti, Garret A FitzGerald
Sep 2, 2011·Revista brasileira de cirurgia cardiovascular : órgão oficial da Sociedade Brasileira de Cirurgia Cardiovascular·Shi-Min Yuan, Hua Jing
Oct 8, 2011·Methodist DeBakey Cardiovascular Journal·Joseph S Fernandez-MoureMark G Davies
Apr 6, 2012·PloS One·Teodora RadonicAeilko H Zwinderman
Apr 28, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Francisco Javier Cubero, Natalia Nieto
Jun 26, 2012·Current Vascular Pharmacology·Alon HendelDavid J Granville
Mar 26, 2013·Lipids in Health and Disease·Arne Torbjørn Høstmark, Anna Haug
Jun 22, 2013·Cardiology Journal·Kálmán BenkeZoltán Szabolcs
Jan 21, 2014·Advances in Experimental Medicine and Biology·Jason B WheelerJeffrey A Jones
Aug 8, 2014·Oxidative Medicine and Cellular Longevity·María Elena SotoIsrael Pérez-Torres
Apr 12, 2015·International Journal of Cardiology·Chrishan J A RamachandraWinston Shim

❮ Previous
Next ❯

Citations

Oct 13, 2018·Physiological Genomics·Marius Catalin StaiculescuJessica E Wagenseil
Jun 6, 2018·International Journal of Environmental Research and Public Health·Israel Pérez-TorresTeresa Imelda Fortoul Vander Goes
Apr 11, 2020·Oxidative Medicine and Cellular Longevity·Maria Elena SotoIsrael Pérez-Torres
Mar 16, 2021·Redox Report : Communications in Free Radical Research·Stefanie S PortelliElizabeth N Robertson
May 29, 2021·Frontiers in Physiology·Israel Pérez-TorresMaría Elena Soto

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
ELISA

Software Mentioned

Sigma Plot

Related Concepts

Related Feeds

Cardiac Aneurysm

Aneurysm refers to a bulge of the wall or lining of a vessel commonly occurring in the blood vessels at the base of the septum or within the aorta. In the heart, it usually arises from a patch of weakened tissue in a ventricular wall, which swells into a bubble filled with blood. Discover the latest research on cardiac aneurysm here.

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.