PMID: 6129943Jan 1, 1982

Participation of beta 2-receptors in the control of rabbit ciliary epithelial permeability

Current Eye Research
K Green, L Mayberry

Abstract

The interaction between several adrenergic agonists (epinephrine, norepinephrine and isoproterenol) and relatively specific beta 1- and beta 2-antagonists has been examined on fluid permeability of the isolated rabbit ciliary epithelium. A specific beta 1-antagonist (metoprolol) had little effect on the permeability increase induced by the agonists, whereas butoxamine (a specific beta 2-antagonist) caused an inhibition of the normal agonist-induced permeability increase. The data suggest that these three adrenergic agonists primarily affect the beta 2-receptor in the ciliary epithelium in order to induce their effects on fluid permeability.

Related Concepts

Adrenergic beta-Agonists
Adrenergic beta-Antagonists
Butoxamine Hydrochloride
Ciliary Body
Mesothelium
Betalok
Permeability
Norepinephrine Receptors
Beta-adrenergic receptor

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