PMID: 3751565Jul 1, 1986Paper

Participation of bone marrow stromal cells in hemopoietic recovery of rats irradiated and then parabiosed with a non-irradiated litter mate. II. Scanning and transmission electron microscopic observations

Acta Pathologica Japonica
K KagawaM Awai

Abstract

A light microscopical study on the recovery process after lethal irradiation and parabiosis has been made. Electron microscopically, in the bone marrow of lethally irradiated rats, hemorrhage occurred due to detachment of sinus endothelial cells. Afterwards, reticulum cells with small intracytoplasmic lipid droplets appeared. On day 3, these cells were rapidly replaced by the reticulum cells with large lipid droplets, and resulted in fatty marrow within 7 days. Spindle-shaped fibroblastoid reticulum cells were also observed. In the bone marrow of lethally irradiated rats parabiosed with non-treated litter mates, hemopoiesis was initiated by adhesion of nucleated blood cells to intricate fine cytoplasmic pseudopods of fat-storage cells. On days 3 to 5, in parallel with progressive hemopoietic recovery, fibroblastoid and reticulum cells with large lipid droplets decreased whereas those with small droplets increased. On day 8, reticulum cells with lipid droplets were seldom seen, and hemopoietic distribution became the same as normal. These results suggested that bone marrow stromal cells, namely reticulum, fat-storage, and fibroblastoid cells share a common cellular origin, and also that they regain their structure and function w...Continue Reading

References

Jan 18, 1979·Nature·M J Cline, D W Golde
Oct 1, 1979·The Journal of Experimental Medicine·H Westen, D F Bainton
Jan 1, 1978·American Journal of Hematology·A BathijaS Trubowitz
Jul 17, 1970·Science·M Tavassoli, W H Crosby
Jan 1, 1974·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·T Murakami
Jun 25, 1966·The Tohoku Journal of Experimental Medicine·Y Watanabe

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