Participation of complement in host defense against encapsulated Haemophilus influenzae types a, c, and d.

Infection and Immunity
C J CorrallE R Moxon

Abstract

Each of the serotypes of Haemophilus influenzae (types a to f) may colonize the respiratory tract of humans, but only type b strains commonly cause invasive systemic infections. To investigate the role of complement in immunity to encapsulated non-type b strains, rats were depleted of C3 with cobra venom factor and challenged with representative serotypes of H. influenzae (type a, b, c, or d) by different routes. After intravenous challenge, rats depleted of C3 had a greater incidence and magnitude of bacteremia with each of the serotypes when compared with normal controls. Intraperitoneal inoculation of type b organisms resulted in meningitis in normal and C3-depleted rats, but only C3-depleted, and not normal, rats developed meningitis after inoculation of serotype a, c, or d. In contrast to systemic inoculation, intranasal challenge with the different serotypes resulted in bloodstream invasion and meningitis only after challenge with type b organisms. These data suggest that complement plays a significant role in immunity to encapsulated, non-type b H. influenzae through its effect on bloodstream clearance.

Citations

Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Derek K HoArnold L Smith
Jan 1, 1984·Infection·A L SmithR D Toothaker
Apr 1, 1993·Clinical Microbiology Reviews·A R Tunkel, W M Scheld
Jul 1, 1987·Journal of Clinical Microbiology·L G RubinN Kamani
Feb 1, 1986·Microbial Pathogenesis·E TuomanenA Tomasz

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