Participation of divalent cation transporter DMT1 in the uptake of inorganic mercury

Toxicology
Marta VázquezS Puig

Abstract

Mercury (Hg) is found in food in various chemical forms, which differ in terms of accumulation, transport, and toxicity. Although methylmercury (CH3Hg) is the predominant mercury species in the diet, contributed mostly by seafood products, there is also a contribution of inorganic mercury [Hg(II)] from vegetables, cereals, and seafood products. The main pathway for exposure to mercury is oral, and therefore the gastrointestinal mucosa is the first barrier that the contaminant meets when it enters the systemic circulation. However, the transport mechanisms responsible for the process of mercury absorption are not known. The aim of this study is to evaluate the possible participation of divalent metal transporter 1 (DMT1) in Hg(II) intestinal uptake. For this purpose, we have used various complementary approaches. We have studied mercury acquisition in a Saccharomyces cerevisiae strain expressing murine DMT1. Moreover, we have evaluated the effect of a reduction of DMT1 expression in Caco-2 cells, by means of small interfering RNA and of treatment with hepcidin, on mercury uptake and transport. The results show that expression of the transporter DMT1 in yeast produces an increase in Hg(II) accumulation. Furthermore, a decrease in...Continue Reading

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Citations

Nov 10, 2015·Toxicology·Archita Venugopal MenonJonghan Kim
Oct 21, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M VázquezV Devesa
Jul 28, 2015·Environmental Science & Technology·Xun Wang, Wen-Xiong Wang
Jul 17, 2016·Archives of Toxicology·Christy C Bridges, Rudolfs K Zalups
Aug 31, 2016·Proceedings of the National Academy of Sciences of the United States of America·Aaron T BozziRachelle Gaudet
Nov 28, 2017·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Mariángeles Ávila ManieroRodolfo G Wuilloud
Jul 25, 2019·Biological Trace Element Research·Sarah E OrrChristy C Bridges
May 5, 2016·Neurotoxicity Research·Jerome A Roth, Richard Salvi
Feb 12, 2021·International Journal of Nanomedicine·Armin Salek MaghsoudiMohammad Abdollahi
Apr 19, 2021·Journal of Molecular Biology·Aaron T Bozzi, Rachelle Gaudet

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