Participation of elderly gynecological cancer patients in clinical trials

Archives of Gynecology and Obstetrics
Katharina PrieskeLinn Woelber

Abstract

Elderly patients are underrepresented in clinical trials in gynecological cancer, even though they are disproportionally often affected. This study aimed to evaluate the disposition and apprehension of elderly patients toward study participation. 112 elderly gynecological cancer patients (median age 70) were surveyed in a multicenter cross-sectional study. Besides fitness, state of disease, education and domestic situation, questions aimed at the general willingness to participate in a clinical trial. Personal reasons for refusal and anticipated advantages/disadvantages that might evolve from participation were inquired. Willingness to participate in a clinical study was generally high (72%, 74/102). Reasons for potential study participation were: 'better monitoring of the disease' (67.1%), 'better medical care' (46.1%), 'to help medical research' (44.7%), 'better medication' (35.5%) and 'because of my doctor's recommendation' (22.4%). Reasons for potential refusal were: 'too time consuming' (24.4%), 'fear of side effects' (21.8%), 'misuse as experimental animal' (18%), 'long distance to clinic' (14.1%) and 'too little or unclear information' (10.3%). 37.2% (29/78) of the patients stated that they had 'no objection' at all agai...Continue Reading

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Citations

Oct 2, 2020·CA: a Cancer Journal for Clinicians·Mina S SedrakUNKNOWN Cancer and Aging Research Group (CARG)
Feb 26, 2019·Archives of Gynecology and Obstetrics·Deepa NarasimhuluJoyce E Balls-Berry
Feb 14, 2021·Health and Quality of Life Outcomes·Ariane Mamguem KamgaTienhan Sandrine Dabakuyo-Yonli
Apr 1, 2021·Expert Review of Gastroenterology & Hepatology·Alessandro RizzoGiovanni Brandi

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