Participation of GABAA-mediated inhibition in ictallike discharges in the rat entorhinal cortex

Journal of Neurophysiology
V Lopantsev, Massimo Avoli

Abstract

The spontaneous, synchronous activity induced by 4-aminopyridine (4AP, 50 microM) in the adult rat entorhinal cortex was analyzed with simultaneous field potential and intracellular recordings in an in vitro slice preparation. Four-AP induced isolated negative-going field potentials (interval of occurrence = 27.6 +/- 9.9 (SD) s; n = 27 slices) that corresponded to intracellular long-lasting depolarizations (LLDs), and ictallike epileptiform discharges (interval of occurrence = 10.4 +/- 5.7 min; n = 27 slices) that were initiated by the negative field potentials. LLDs recorded with K-acetate-filled microelectrodes triggered few action potentials of variable amplitude and had a duration of 1.7 +/- 0.8 s (n = 26 neurons), a peak amplitude of 11.8 +/- 5.0 mV (n = 26 neurons) and a reversal potential of -66.2 +/- 3.9 mV (n = 17 neurons). The ictal discharges studied with K-acetate microelectrodes consisted of prolonged depolarizations (duration = 72.9 +/- 44.3 s; peak amplitude = 29.2 +/- 11.4 mV; n = 25 neurons) with action-potential firing during both the tonic and the clonic phase. These depolarizations had a reversal potential of -45.3 +/- 3.8 mV (n = 4 neurons). Intracellular Cl- diffusion from KCl-filled microelectrodes made b...Continue Reading

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Citations

Jun 4, 2004·Brain : a Journal of Neurology·M D'AntuonoM Avoli
Apr 28, 2006·Journal of Neurophysiology·Hui XiangSteven N Roper
Oct 12, 2007·Physiological Reviews·Yehezkel Ben-AriRustem Khazipov
Mar 18, 2009·The European Journal of Neuroscience·Laura UvaMarco de Curtis
Jul 19, 2011·Neural Plasticity·R WrightC J Akerman
Sep 14, 2012·Journal of Neurophysiology·Alfredo Gonzalez-SulserRhonda Dzakpasu
Jun 24, 2017·The European Journal of Neuroscience·Maxime LévesqueMassimo Avoli
Mar 24, 2006·Journal of Neurophysiology·Jokubas ZiburkusSteven J Schiff
Jan 30, 2007·Epilepsy Currents·Massimo AvoliM de Curtis
Feb 2, 2008·The Journal of Physiology·Philip de GuzmanMassimo Avoli
Jan 31, 2009·Epilepsia·Gabriella PanuccioMassimo Avoli
Dec 12, 2012·Journal of Neurophysiology·Jokubas ŽiburkusSteven J Schiff
Jun 4, 2015·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Andrew J TrevelyanKevin J Staley
Apr 12, 2016·Epilepsia·Marco de Curtis, Massimo Avoli
Dec 4, 2002·Epilepsia·Michaela BarbarosieMassimo Avoli
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Aug 22, 2009·Epilepsia·Margherita D'AntuonoMassimo Avoli
Apr 27, 2002·Journal of Neurophysiology·Lisa A Gabel, Joseph J LoTurco
Mar 24, 2009·The European Journal of Neuroscience·Valeri LopantsevAndreas Draguhn
Jan 15, 2014·Epilepsia·Vadym GnatkovskyStefano Francione
Sep 5, 2018·Annals of Neurology·Bahareh ElahianShennan A Weiss
Dec 25, 2008·Annals of Neurology·Vadym GnatkovskyMarco de Curtis
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Oct 19, 2017·Neurobiology of Disease·Oscar C GonzálezMaxim Bazhenov
Feb 12, 2019·Neurobiology of Disease·Marco de CurtisVadym Gnatkovsky
Mar 27, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Anca A ArbuneSándor Beniczky
Jul 11, 2012·Neuropharmacology·Massimo AvoliRüdiger Köhling
May 1, 2021·Experimental Neurology·Laura UvaMarco de Curtis

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