PMID: 8613678Mar 1, 1996Paper

Participation of gap-junctional cell communication on the adaptive response in human cells induced by low dose of X-rays

International Journal of Radiation Biology
K Ishii, M Watanabe

Abstract

To investigate the radioadaptive response of normal cells to low-dose radiation, we irradiated human embryonic (HE) cells and HeLa cells with low-dose X-rays and examined the changes in sensitivity to subsequent high-dose X-irradiation using the trypan blue dye-exclusion test. When HE cells were irradiated by 200 cGy, the growth ratio of the living cells 5 days after the irradiation decreased to 37% of that of the cells which received no X-irradiation. When the cells received a conditioning irradiation of 10-20 cGy 4 h before the irradiation of 200 cGy, the relative growth ratios increased significantly to 45-53%, and a peak was reached at a conditioning dose of 13 cGy to the cells. This conditioning effect was not observed in LeLa cells. When the HE cells were suspended in a Ca2+ ion-free medium or TPA added to the medium while receiving the conditioning irradiation of 13 cGy, the effect of the conditioning dose was not observed. This indicates that normal cells show an adaptive response to low-dose radiation and become more radioresistant. These results suggest that gap junctional intercellular communication may play a role in radioadaptive responses in human cells.

References

Nov 1, 1991·Mutation Research·S Z Aghamohammadi, J R Savage
Jul 1, 1989·International Journal of Radiation Biology·J D Shadley, J K Wiencke
Aug 11, 1989·Science·L A Sagan
Mar 1, 1989·Mutation Research·A Bosi, G Olivieri
Mar 1, 1989·Mutation Research·K SankaranarayananA T Natarajan
Jan 1, 1988·Annual Review of Biochemistry·T LindahlY Nakabeppu
Jan 1, 1988·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·L E FeinendegenH Mühlensiepen
Jun 1, 1994·Cancer Metastasis Reviews·P L Olive, R E Durand

❮ Previous
Next ❯

Citations

Jun 9, 2006·Acta Oncologica·Bozidar Djordjevic, Christopher S Lange
May 17, 2013·Environmental and Molecular Mutagenesis·Pamela L HeardMaik J Schuler
Feb 23, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B Djordjevic
Jan 10, 2004·International Journal of Radiation Biology·D GloverN Gueven
Jun 7, 2013·Environmental and Molecular Mutagenesis·George R HoffmannJason P Tartaglione
Aug 4, 2007·Critical Reviews in Toxicology·Guangwei LiuLu Cai
Apr 4, 2009·Dose-response : a Publication of International Hormesis Society·George R Hoffmann
Mar 13, 2009·International Journal of Radiation Biology·Claudia A GrilloAlba M Guerci
Apr 12, 2014·PLoS Computational Biology·Dominik WodarzNatalia L Komarova
Jan 24, 2006·Preparative Biochemistry & Biotechnology·Eui-Chul ParkEun-Mi Park
Aug 10, 2013·Dose-response : a Publication of International Hormesis Society·Smj MortazaviM Shafie
Dec 23, 2004·Journal of Radiation Research·Yuri Miura
Nov 10, 2012·Journal of Radiation Research·Narongchai AutsavaprompornEdouard I Azzam
Dec 10, 1999·Micron : the International Research and Review Journal for Microscopy·Z Somosy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.