Participation of mercuric conjugates of cysteine, homocysteine, and N-acetylcysteine in mechanisms involved in the renal tubular uptake of inorganic mercury.

Journal of the American Society of Nephrology : JASN
Rudolfs K Zalups, D W Barfuss

Abstract

Mechanisms involved in the renal uptake of inorganic mercury were studied in rats administered a nontoxic 0.5 mumol/kg intravenous dose of inorganic mercury with or without 2.0 mumol/kg cysteine, homocysteine, or N-acetylcysteine. The renal disposition of mercury was studied 1 h after treatment in normal rats and rats that had undergone bilateral ureteral ligation. In addition, the disposition of mercury (including the urinary and fecal excretion of mercury) was evaluated 24 h after treatment. In normal rats, coadministering inorganic mercury plus cysteine or homocysteine caused a significant increase in the renal uptake of mercury 1 h after treatment. The enhanced renal uptake of mercury was due to increased uptake of mercury in the renal outer stripe of the outer medulla and/or renal cortex. Ureteral ligation caused reductions in the renal uptake of mercury in all groups except for the one treated with inorganic mercury plus N-acetylcysteine. Thus, it appears that virtually all of the mercury taken up by the kidneys of the normal rats treated with inorganic mercury plus N-acetylcysteine occurred at the basolateral membrane. Urinary excretory data also support this notion, in that the rate of excretion of inorganic mercury was...Continue Reading

Citations

Aug 26, 1998·Toxicology and Applied Pharmacology·R K Zalups
Mar 7, 2000·Journal of the American Society of Nephrology : JASN·Vernon T CannonRudolfs K Zalups
Mar 31, 2000·Toxicology and Applied Pharmacology·R K Zalups
Oct 25, 2002·Journal of Toxicology and Environmental Health. Part a·Rudolfs K Zalups, Delon W Barfuss
Mar 7, 2003·Toxicology and Applied Pharmacology·Rudolfs K Zalups, Sarfaraz Ahmad
Apr 23, 2005·Toxicology and Applied Pharmacology·Christy C Bridges, Rudolfs K Zalups
Jan 31, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·George Fotakis, John A Timbrell
Feb 10, 2006·Toxicology and Applied Pharmacology·Rudolfs K Zalups, Lawrence H Lash
Feb 15, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·P A ChykaM I Herman
Aug 6, 2005·The Journal of Pharmacology and Experimental Therapeutics·Rudolfs K Zalups, Sarfaraz Ahmad
Sep 16, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lawrence H LashRudolfs K Zalups
Sep 17, 2005·Kidney International·Rudolfs K Zalups, Sarfaraz Ahmad
May 13, 2017·International Journal of Molecular Sciences·Sarah E Orr, Christy C Bridges
Jul 15, 2006·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Ricardo BrandãoCristina W Nogueira
Aug 24, 2006·The Journal of Pharmacology and Experimental Therapeutics·Christy C Bridges, Rudolfs K Zalups
Jun 7, 2012·Chemical Research in Toxicology·Rudolfs K Zalups, Christy C Bridges
May 31, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christy C BridgesRudolfs K Zalups
Jun 29, 2010·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Christy C Bridges, Rudolfs K Zalups
Nov 9, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ricardo Brandão, Cristina W Nogueira
Jan 25, 2011·Journal of Applied Toxicology : JAT·Ricardo BrandãoCristina W Nogueira
Oct 7, 2004·The American Journal of Pathology·Christy C Bridges, Rudolfs K Zalups

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