Jun 1, 1976

Participation of mouse T- and B-lymphocytes in the graft versus host reaction

Biulleten' eksperimental'noĭ biologii i meditsiny
M S Bliakher


Cells of the spleen or lymph nodes of CBA mice were transplanted to sublethally irradiated (CBAXC57BL/6)F1 mice; this caused development of the graft-versus-host reaction (GVHR). Lymphocytes lost the capacity to realize this reaction after in vitro treatment with specific sera against mouse T- and B-lymphocytes. Apparently, development of the GVHR in mice was connected with the cooperative interaction of T- and B-lymphocytes.

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Mentioned in this Paper

Mice, Inbred CBA
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Hybridization, Intraspecies
Graft Vs Host Reaction
Phosphoglycerate Dehydrogenase Activity
Lymph Nodes
PHGDH wt Allele

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