PMID: 7539398Jun 1, 1995Paper

Participation of small intraportal stem cells in the restitutive response of the liver to periportal necrosis induced by allyl alcohol

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
L YavorkovskyS Sell

Abstract

To determine the involvement of different hepatocyte populations in response to periportal injury, the restitutive response to allyl alcohol (AA) injury was examined. Adult female Sprague-Dawley rats were injected intraperitoneally (IP) with 0.62 mmol/kg AA, killed at 6, 9, 12, 33, 57, 81, and 153 hours after injection, and the livers were examined for injury and for restitutive proliferation by histology, autoradiography, and immunohistochemistry to detect alpha-fetoprotein (AFP), glutathione-s-transferase-p (GST-p), desmin, leukocyte common antigen, albumin, and monoclonal antibodies to liver cells: OV-6, H-4, and T-6. AA produces variable periportal liver necrosis predominantly at 6 to 12 hours. Proliferation of hepatocytes throughout the hepatic cord is seen early after injury in nonnecrotic areas: predominantly in zone II, but also in zones I and III, including some cells adjacent to the central vein. Within 2 to 3 days the necrotic zones are filled with small cells and by 1 week the liver architecture is essentially restored. During the active restitutive reaction from the immediate periportal rim the following cell phenotypes are seen: null cells: -->(AFP+, OV-6-, GST-p-) cells-->(AFP-, OV-6+, GST-p+) cells-->large (AFP-...Continue Reading

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Citations

Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L YinS Sell
Feb 14, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S Sell
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B E PetersenG K Michalopoulos
Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H A CrosbyA J Strain
Apr 12, 2002·Journal of Hepatology·David A Shafritz, Mariana D Dabeva
Feb 27, 1999·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·T WerlichG Machnik
Jan 18, 2003·The International Journal of Biochemistry & Cell Biology·Stewart Sell
Jul 23, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A C PiscagliaA Gasbarrini
Nov 13, 2008·Cytotechnology·Neil D Theise
Jan 10, 2003·Journal of Gastroenterology and Hepatology·Kym N LowesGeorge C T Yeoh
Dec 17, 2003·Journal of Gastroenterology and Hepatology·Paul S HaberGeoffrey W McCaughan
Mar 19, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·S Sell
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D RosenbergS Sell
Sep 19, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S BadveR Saxena
Jul 31, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M AlisonC Sarraf
Jun 11, 2005·Journal of Gastroenterology and Hepatology·Shigeki MiyamotoToshihiro Mitaka
Jul 10, 2008·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Stewart Sell
Dec 7, 2013·Stem Cells International·Eva KoellenspergerUwe Leimer
Dec 7, 2002·Seminars in Cell & Developmental Biology·Neil D Theise, Diane S Krause
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Li YinStewart Sell
Mar 16, 2001·In Vitro Cellular & Developmental Biology. Animal·R Gil-BensoA Llombart-Bosch
Feb 10, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Aránzazu SánchezSnorri S Thorgeirsson
Dec 31, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Masaki HataNobuyuki Terada
May 7, 1998·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·T WerlichG Machnik
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Feb 29, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·M Behnan SahinCatherine M Verfaillie
Sep 29, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yixin ChenM Behnan Sahin
Jun 30, 2006·Biochemical and Biophysical Research Communications·Atsushi HosuiNorio Hayashi
Oct 6, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C Di CampliA Gasbarrini
Jun 23, 2004·Critical Reviews in Oncology/hematology·Stewart Sell
Nov 17, 2009·Journal of Hepatology·Laurent DolléAlbert Geerts

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