Participation of urinary Na+, K+, pH, and L-ascorbic acid in the proliferative response of the bladder epithelium after the oral administration of various salts and/or ascorbic acid to rats

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
M A ShibataS Fukushima

Abstract

Changes in urinary parameters (particularly electrolyte levels and pH), and DNA synthesis and the morphology of the bladder epithelium were investigated in rats that were fed for 4 or 8 wk on diets containing various Na, K, Mg or Ca carbonate salts, with or without L-ascorbic acid (AsA). [The carbonate salts were fed at a level of 3% in the diet, and AsA or AsA-Na was administered at 5% in the diet. NH4Cl was at 1% in the diet.] The effects of treatment with NH4Cl (used as a urine acidifier), and of combined treatment with sodium ascorbate (AsA-Na) and NH4Cl were also investigated. Urinary pH was significantly elevated in groups given NaHCO3, K2CO3, AsA + NaHCO3, AsA + K2CO3 and AsA-Na, whereas treatment with AsA or NH4Cl alone caused a significant drop in urinary pH. An increase in urinary electrolytes or ascorbic acid was associated with the corresponding dosing regimen. DNA synthesis in the bladder epithelium was increased in groups given NaHCO3, K2CO3, AsA + NaHCO3, AsA + K2CO3 or AsA-Na. Furthermore, all treatments that induced an elevation of DNA synthesis also induced some morphological alterations in the bladder epithelium. The administration of AsA in conjunction with NaHCO3 or K2CO3 induced levels of change greater th...Continue Reading

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Citations

Apr 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G R Lankas, C P Peter
Dec 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B A LinaR A Woutersen
May 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M A ShibataT Shirai
Jun 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K TakabaS Fukushima
Feb 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S ShioyaS Fukushima
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