Particle characteristics and biodistribution of camptothecin-loaded PLA/(PEG-PPG-PEG) nanoparticles

Drug Delivery
Ryotaro KuniiYoshiharu Machida

Abstract

Poly(DL-lactic acid) (PLA)/poly(ethylene glycol)-block-poly (propylene glycol)-block-poly(ethylene glycol) copolymer (PEG-PPG-PEG) nanoparticles loaded with camptothecin (CPT), called CPT-NP, were prepared and examined for particle size change and drug release in phosphate-buffered saline, pH 7.4, (PBS), and drug biodistribution profiles in mice bearing sarcoma 180 solid tumor. CPT-NP kept an almost constant mean size and exhibited an initial rapid release of approximately 20%, following by very slow release. As compared with CPT solution, CPT-NP showed higher tissue accumulation and better tumor localization, which were considered essentially associated with the better efficacy of CPT-NP reported in the previous study.

References

Jun 1, 1991·Journal of Pharmacobio-dynamics·T TsujiD Tsuru
Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·Y TabataY Ikada
May 20, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·S C YangC Z Yang
Oct 16, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·Y KawashimaT Hino
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·V R CaiolfaA Suarato
Apr 1, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·Y MachidaY Machida
Aug 5, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·N KunouY Ikada
May 19, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hidetaka MiuraYoshiharu Machida

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