PMID: 9525760Apr 3, 1998Paper

Particle motion within in vitro models of stenosed internal carotid and left anterior descending coronary arteries

Annals of Biomedical Engineering
J Cao, S E Rittgers

Abstract

Asymmetric 75% and 95% area reduction, transparent Sylgard stenotic models were operated under internal carotid artery (ICA) [Womersley parameter, alpha=5.36, Re(mean) =213 and 180, respectively, and Re(peak)=734 and 410, respectively] and left anterior descending coronary artery (LAD) flow wave forms (alpha=2.65, Re(mean)=59 and 57, respectively, and Re(peak)= 137 and 94, respectively) to evaluate the effect of these conditions on particle residence times downstream of the stenoses. Amberlite particles (1.05 g/cm3, 400 microm) were added to the fluid to simulate platelets and their motion through the stenotic region and were traced using a laser light sheet flow visualization method with pseudo-color display. Two-dimensional (2D) particle motions were recorded and particle washout in the stenotic throat and downstream section were computed for all cases. All four model cases demonstrated jetting through the stenosis which followed an arching pattern around a large separation zone downstream. Considerable mixing was observed within these vortex regions during high flow phases. Particle washout profiles showed no clear trend between the degrees of stenosis although particles downstream of the stenoses tended to remain longer for...Continue Reading

Citations

Feb 9, 2007·Annals of Biomedical Engineering·Sagi RazDanny Bluestein
Apr 6, 2002·Journal of Biomechanics·Dieter Liepsch
Nov 10, 2001·Annual Review of Biomedical Engineering·D M Wootton, D N Ku
Mar 29, 2012·Computational and Mathematical Methods in Medicine·Woowon Jeong, Kyehan Rhee
Jul 6, 2014·Critical Care Clinics·Jeffrey J Teuteberg, Josephine C Chou
Jun 18, 2004·Annals of the New York Academy of Sciences·Shmuel Einav, Danny Bluestein
Oct 12, 2004·Ultrasound in Medicine & Biology·Tamie L PoeppingDavid W Holdsworth
Jul 11, 2016·Medical Engineering & Physics·Xiaopeng TianYubo Fan
May 26, 2017·Biotechnology and Bioengineering·Hamid Hosseinzadegan, Danesh K Tafti
May 23, 2007·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Andrea GarattiEttore Vitali
Jul 26, 2014·Annals of Biomedical Engineering·Shawn C Shadden, Amirhossein Arzani
Oct 17, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A J HaughtonM J Walker
Jul 17, 2020·Scientific Reports·Javad HashemiR Eric Berson

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