Particle radiation therapy using proton and heavier ion beams
Abstract
Particle beams like protons and heavier ions offer improved dose distributions compared with photon (also called x-ray) beams and thus enable dose escalation within the tumor while sparing normal tissues. Although protons have a biologic effectiveness comparable to photons, ions, because they are heavier than protons, provide a higher biologic effectiveness. Recent technologic developments in the fields of accelerator engineering, treatment planning, beam delivery, and tumor visualization have stimulated the process of transferring particle radiation therapy (RT) from physics laboratories to the clinic. This review describes the physical, biologic, and technologic aspects of particle beam therapy. Clinical trials investigating proton and carbon ion RT will be summarized and discussed in the context of their relevance to recent concepts of treatment with RT.
References
Spot-scanning proton radiation therapy for recurrent, residual or untreated intracranial meningiomas
Citations
The influence of hyperglycemia during radiotherapy on survival in patients with primary glioblastoma
Dosimetric comparison of photon and proton treatment techniques for chondrosarcoma of thoracic spine
Carbon ion radiotherapy for pediatric patients and young adults treated for tumors of the skull base
Carbon-ion beam treatment induces systemic antitumor immunity against murine squamous cell carcinoma
Acute pulmonary and splenic response in an in vivo model of whole-body low-dose X-radiation exposure
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