PMID: 8942886Nov 1, 1996Paper

Particle size and drug interactions of injectable corticosteroids used in ophthalmic practice

Ophthalmology
B A FrancisB G Haik

Abstract

The aim of this study is to compare the particle sizes of commercially available corticosteroids for intralesional injection to manufacturers' specifications and to evaluate changes in size when mixed with other steroids and other commonly used solutions. The particle sizes of dexamethasone sodium phosphate, methylprednisolone acetate, triamcinolone acetonide, and betamethasone sodium phosphate and beta-methasone acetate were measured with the Coulter counter. Each steroid was mixed with each of the others, lidocaine, and lidocaine with epinephrine, then measured immediately and after 1 hour to determine the effect on particle size. All steroids showed accurate manufacturer specifications. Dexamethasone showed an increase in particle size when mixed with lidocaine alone, immediately and after 1 hour. Triamcinolone showed an increase in particle size only after 1 hour after mixture with lidocaine alone. Triamcinolone, dexamethasone, and methylprednisolone particles increased in size when mixed with lidocaine and epinephrine. Dexamethasone and triamcinolone showed an additional increase in size when allowed to sit for 1 hour after mixture with lidocaine and epinephrine. Mixing steroids caused no increase in particle size. Because...Continue Reading

Citations

Mar 21, 2000·Medical & Biological Engineering & Computing·S PaulJ E Egbert
Jun 15, 1999·Medical & Biological Engineering & Computing·S PaulM F Hoey
Mar 15, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Yannis AthanasiadisParwez Hossain
Apr 18, 2009·Retina·Andrew A MoshfeghiDarius M Moshfeghi
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Jan 23, 2021·Ophthalmic Plastic and Reconstructive Surgery·Sally S E Park, Anne Barmettler
Sep 4, 2010·Journal de radiologie·M Wybier

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