Particle transport in the human respiratory tract: formulation of a nodal inverse distance weighted Eulerian-Lagrangian transport and implementation of the Wind-Kessel algorithm for an oral delivery

International Journal for Numerical Methods in Biomedical Engineering
Ravishekar KannanAndrzej Przekwas

Abstract

This paper is the first in a series wherein efficient computational methods are developed and implemented to accurately quantify the transport, deposition, and clearance of the microsized particles (range of interest: 2 to 10 µm) in the human respiratory tract. In particular, this paper (part I) deals with (i) development of a detailed 3D computational finite volume mesh comprising of the NOPL (nasal, oral, pharyngeal and larynx), trachea and several airway generations; (ii) use of CFD Research Corporation's finite volume Computational Biology (CoBi) flow solver to obtain the flow physics for an oral inhalation simulation; (iii) implement a novel and accurate nodal inverse distance weighted Eulerian-Lagrangian formulation to accurately obtain the deposition, and (iv) development of Wind-Kessel boundary condition algorithm. This new Wind-Kessel boundary condition algorithm allows the 'escaped' particles to reenter the airway through the outlets, thereby to an extent accounting for the drawbacks of having a finite number of lung generations in the computational mesh. The deposition rates in the NOPL, trachea, the first and second bifurcation were computed, and they were in reasonable accord with the Typical Path Length model. The...Continue Reading

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Citations

Sep 12, 2018·International Journal for Numerical Methods in Biomedical Engineering·Arnau PontAnnemie van Hirtum
May 11, 2019·Journal of Biomechanical Engineering·Bora SulAnders Wallqvist
Jun 4, 2019·Biomechanics and Modeling in Mechanobiology·A Pandal-BlancoA Fernández-Tena
Feb 6, 2020·International Journal for Numerical Methods in Biomedical Engineering·Ravishekar Kannan, Andrzej Przekwas
Feb 14, 2020·International Journal for Numerical Methods in Biomedical Engineering·Ravishekar KannanJulia Hoeng
Apr 3, 2020·International Journal for Numerical Methods in Biomedical Engineering·Ana Fernández-TenaAdrián Pandal-Blanco
Jul 9, 2016·Respiratory Research·Sophie PerinelJérémie Pourchez
Oct 6, 2016·International Journal for Numerical Methods in Biomedical Engineering·Ravishekar KannanRoss Walenga
Dec 23, 2017·International Journal for Numerical Methods in Biomedical Engineering·Ravishekar Ravi KannanAndrzej Przekwas
Nov 20, 2016·International Journal for Numerical Methods in Biomedical Engineering·Jessica M OakesIrene E Vignon-Clementel
Jun 3, 2017·International Journal for Numerical Methods in Biomedical Engineering·E Sanmiguel-RojasF Esteban-Ortega
Nov 7, 2017·Biomechanics and Modeling in Mechanobiology·A Fernández-TenaC Ferrera
Nov 19, 2020·International Journal for Numerical Methods in Biomedical Engineering·Jingliang DongJiyuan Tu

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