Particles for Local Delivery of Proteins Using Intra-Articular Route

Advanced Healthcare Materials
Khosrow KhodabandehlouJoseph M DeSimone

Abstract

Designing a vehicle for local delivery of proteins using intra-articular route is an attractive option to minimize the adverse effects associated with systemic exposure and to maximize the efficacy. Slowly dissolving silylated microparticles are designed with specific size and shape that are capable of extending the retention time of a model protein (bovine serum albumin) in the murine knee joint. No cytotoxicity is observed for the reconstituted formulation when tested against synovial fibroblasts and RAW 264.7 macrophages.

References

Dec 1, 1987·Annals of the Rheumatic Diseases·D P Page-ThomasJ T Dingle
Jan 1, 1987·Arthritis and Rheumatism·W J WallisW B Nelp
Nov 1, 1969·Annals of the Rheumatic Diseases·D L BrownR Bluestone
Jul 1, 1984·The Journal of Pharmacy and Pharmacology·J H RatcliffeS S Davis
Nov 1, 1984·The Journal of Clinical Investigation·W B van den BergL A Joosten
Jul 1, 1994·Journal of Microencapsulation·F PavanettoU Conte
Oct 23, 1997·The Journal of Bone and Joint Surgery. British Volume·H M Van Der VisC J Van Noorden
Mar 30, 2000·Journal of Microencapsulation·M TunçayA A Hincal
Oct 10, 2002·Journal of Structural Biology·Gino CingolaniJohn E Johnson
Apr 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andreas WunderChristoph Fiehn
Apr 1, 1960·Arthritis and Rheumatism·G P RODNAN, M J MACLACHLAN
Aug 4, 2004·British Journal of Pharmacology·Michael Poteser, Ichiro Wakabayashi
Aug 19, 2004·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·R T LigginsH M Burt
Apr 1, 2006·Advanced Drug Delivery Reviews·Nicole GerwinAndrea Lucke
Feb 5, 2008·Nature Materials·Dominique A RothenfluhJeffrey A Hubbell
Feb 29, 2008·Journal of Pharmaceutical Sciences·Claus LarsenPia H Andersen
Apr 2, 2008·Journal of the American Chemical Society·Jennifer Y Kelly, Joseph M DeSimone
Feb 25, 2009·Expert Opinion on Drug Delivery·Helen M BurtLinda S Liang
Jun 24, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·N ButoescuE Doelker
Nov 10, 2009·Nature Medicine·Stephanie LefèvreElena Neumann
Jun 4, 2011·Molecular Pharmaceutics·Jolanda M van den HovenGert Storm
Dec 6, 2011·Archives of Pharmacal Research·Samir Mitragotri, Jin-Wook Yoo
May 2, 2012·Journal of the American Chemical Society·Matthew C ParrottJoseph M DeSimone
Jul 24, 2012·Biomaterials·Rachel E WhitmireAndrés J García
Nov 6, 2013·Nature Reviews. Rheumatology·Christopher H EvansLori A Setton
Mar 6, 2015·ACS Applied Materials & Interfaces·Khosrow KhodabandehlouJoseph M DeSimone

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