Particular Morphological Features in the Diagnosis of Pediatric Helicobacter pylori Gastritis: A Morphometry-Based Study

Journal of Clinical Medicine
Ana-Maria Teodora DomșaCristina Maria Borzan

Abstract

Current pediatric guidelines recommend the use of the Updated Sydney Classification for gastritis to assess histological changes caused by Helicobacter pylori (H. pylori) infection. The purpose of this study was to investigate the morphometric alterations of the antral mucosa in relation to pediatric H. pylori infection. A total of 65 cases were considered eligible. Apart from scoring the biopsies according to the recommendations, foveolar hyperplasia (FH) was assessed. The following measurements were performed on digital slides: total mucosal thickness, foveolar and glandular length, number of glandular cross sections per 40X field, glandular diameter, and distance between glands. The thickness of the antral mucosa increased along with the bacterial density and the intensity of inflammation in H. pylori-infected children (p < 0.05). FH was significantly associated with the presence of H. pylori (p < 0.001) and also exhibited a greater length of the foveolar and glandular structures and an increased glandular diameter (p < 0.05), but without influencing the thickness of the mucosa. Our results reinforce the fact that FH is not only an important histologic characteristic of gastropathy, but is also a significant change observed ...Continue Reading

References

May 1, 1986·Journal of Clinical Pathology·M F DixonD Johnston
Nov 10, 2000·Annals of Diagnostic Pathology·A E WhitneyB D Gold
Aug 31, 2006·Seminars in Diagnostic Pathology·Robert M Genta
Apr 2, 2010·Gut Pathogens·Mohammed Mahdy KhalifaRamy Karam Aziz
Jul 28, 2010·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Yolanda Jaramillo-RodríguezLuis Enrique Manríquez-Covarrubias
Nov 26, 2010·Helicobacter·Petronella Mourad-BaarsNicola L Jones
Dec 23, 2011·Journal of Digestive Diseases·Pelayo Correa, M Blanca Piazuelo
Nov 28, 2013·Gut Microbes·Paul R HarrisGuillermo I Perez-Perez
Aug 30, 2014·Helicobacter·Barbara Iwańczak, Ruggiero Francavailla
May 26, 2017·Journal of Pediatric Gastroenterology and Nutrition·Nicola L JonesUNKNOWN ESPGHAN, NASPGHAN

❮ Previous
Next ❯

Citations

Jun 30, 2021·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Gonzalo Galicia PobletAna María Vegas Álvarez
Oct 14, 2021·Anales De Pediatría·Gonzalo Galicia PobletAna María Vegas Álvarez

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

R Commander
R
ProPlus
Case Viewer

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.