Particulate matter exposure impairs systemic microvascular endothelium-dependent dilation

Environmental Health Perspectives
Timothy R NurkiewiczMatthew A Boegehold

Abstract

Acute exposure to airborne pollutants, such as solid particulate matter (PM), increases the risk of cardiovascular dysfunction, but the mechanisms by which PM evokes systemic effects remain to be identified. The purpose of this study was to determine if pulmonary exposure to a PM surrogate, such as residual oil fly ash (ROFA), affects endothelium-dependent dilation in the systemic microcirculation. Rats were intratracheally instilled with ROFA at 0.1, 0.25, 1 or 2 mg/rat 24 hr before experimental measurements. Rats intratracheally instilled with saline or titanium dioxide (0.25 mg/rat) served as vehicle or particle control groups, respectively. In vivo microscopy of the spinotrapezius muscle was used to study systemic arteriolar dilator responses to the Ca2+ ionophore A23187, administered by ejection via pressurized micropipette into the arteriolar lumen. We used analysis of bronchoalveolar lavage (BAL) samples to monitor identified pulmonary inflammation and damage. To determine if ROFA exposure affected arteriolar nitric oxide sensitivity, sodium nitroprusside was iontophoretically applied to arterioles of rats exposed to ROFA. In saline-treated rats, A23187 dilated arterioles up to 72 +/- 7% of maximum. In ROFA- and TiO2-exp...Continue Reading

References

Jun 1, 1991·Journal of Applied Physiology·J M Lash, A A Shoukas
May 1, 1991·The Journal of Clinical Investigation·E VicautA Tedgui
Nov 1, 1986·Microvascular Research·T C Skalak, G W Schmid-Schönbein
Feb 1, 1995·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R F HendersonE B Barr
Feb 1, 1994·International Journal of Cardiology·H SuzukiT Katagiri
Sep 1, 1996·International Journal of Microcirculation, Clinical and Experimental·J R Linderman, M A Boegehold
Feb 21, 1997·Journal of Toxicology and Environmental Health·K L DreherD L Costa
Apr 1, 1997·American Journal of Respiratory and Critical Care Medicine·T TerashimaS F van Eeden
Jan 24, 1998·Circulation Research·E J KunkelK Ley
Feb 24, 1998·Stroke; a Journal of Cerebral Circulation·J E Brian, F M Faraci
May 9, 1998·Respiration Physiology·C A KindigD C Poole
Aug 26, 1998·Toxicological Sciences : an Official Journal of the Society of Toxicology·U P KodavantiD L Costa
Mar 12, 1999·Journal of Molecular and Cellular Cardiology·H Drexler, B Hornig
Aug 13, 1999·Journal of Applied Physiology·C A KindigD C Poole
Apr 14, 2000·American Journal of Respiratory and Critical Care Medicine·W C TanJ C Hogg
Jun 28, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·S Y GardnerD L Costa
Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·T R Nurkiewicz, M A Boegehold
Aug 3, 2000·American Journal of Physiology. Heart and Circulatory Physiology·B A Sauls, M A Boegehold
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J K BaileyD C Poole
Dec 15, 2000·The New England Journal of Medicine·J M SametS L Zeger
Jan 3, 2001·Medicinal Research Reviews·C E HillS L Sandow
Jan 6, 2001·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·T Matsuki, B R Duling
May 16, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·L Calderón-GarcidueñasR B Devlin
Jul 31, 2001·Human & Experimental Toxicology·A M KnaapenP J Borm
Sep 7, 2001·Environmental Health Perspectives·D W Dockery
Sep 11, 2001·American Journal of Respiratory and Critical Care Medicine·S F van EedenJ C Hogg
Mar 19, 2002·Journal of the American College of Cardiology·Tatsushi SuwaStephan F van Eeden
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Annemiek J M CornelissenJos A E Spaan
Aug 2, 2002·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Russell L PrewittAnca D Dobrian
Oct 22, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·James M AntoniniRobert W Clarke
Oct 25, 2002·Journal of Toxicology and Environmental Health. Part a·W G KreylingA Ziesenis
Oct 25, 2002·Journal of Toxicology and Environmental Health. Part a·Günter OberdörsterChristopher Cox
Oct 25, 2002·Journal of Toxicology and Environmental Health. Part a·Magda M W UlrichFlemming R Cassee
Oct 25, 2002·Journal of Toxicology and Environmental Health. Part a·Stephan F van Eeden, James C Hogg

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Citations

Aug 9, 2012·Future Cardiology·Mark R MillerJeremy P Langrish
Jul 19, 2013·BioMed Research International·Abderrahim NemmarErnesto Alfaro-Moreno
Mar 2, 2006·Environmental Health Perspectives·Timothy R NurkiewiczMatthew A Boegehold
Dec 23, 2006·Environmental Health Perspectives·Maureen R Gwinn, Val Vallyathan
Mar 4, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Dovenia S PonnothS Jamal Mustafa
May 2, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Clarke G TankersleyWayne Mitzner
Feb 3, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Zhekang YingSanjay Rajagopalan
Mar 10, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Timothy R NurkiewiczVincent Castranova
Jun 13, 2009·American Journal of Respiratory Cell and Molecular Biology·Ting WangJoe G N Garcia
Dec 4, 2012·International Journal of Molecular Sciences·Phoebe A StapletonTimothy R Nurkiewicz
Sep 27, 2007·Reviews on Environmental Health·Robert D Brook
Jul 25, 2007·Cardiovascular Toxicology·William H RowanWilliam P Watkinson
May 7, 2013·Cardiovascular Toxicology·Valerie C MinarchickTimothy R Nurkiewicz
Jan 1, 2010·Air Quality, Atmosphere, & Health·Jesus A Araujo
Dec 15, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lindsay Wichers StanekDaniel L Costa
Jul 5, 2005·American Journal of Respiratory and Critical Care Medicine·Francesco ForastiereCarlo A Perucci
Oct 4, 2007·Inhalation Toxicology·Wayne E CascioChristopher J Wingard
Dec 16, 2006·Inhalation Toxicology·Kenneth W RundellAmanda M Hollenbach
May 24, 2006·Inhalation Toxicology·Kenneth W RundellKerri Murphy
Oct 5, 2010·Vascular Pharmacology·Surovi HazarikaChristopher J Wingard
Nov 26, 2015·Journal of Toxicology and Environmental Health. Part a·K L PorterD A Jackson
Nov 13, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Srikanth S NadadurDaniel L Costa
Jan 8, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·John M VeranthGarold S Yost
Jun 5, 2007·Translational Research : the Journal of Laboratory and Clinical Medicine·Emily CozziRuth Ann Henriksen
Jan 20, 2007·Toxicology and Applied Pharmacology·Christian S HansenSteffen Loft
Nov 10, 2013·Paediatrics and International Child Health·Roya KelishadiMaryam Fakhri
Sep 17, 2015·Toxicology and Applied Pharmacology·P A StapletonT R Nurkiewicz
Aug 28, 2010·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Charles L Geraci, Vincent Castranova
Aug 27, 2011·Inhalation Toxicology·Paul T CutrufelloGeorgios A Stylianides

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Methods Mentioned

BETA
bronchoalveolar lavage
scanning electron microscopy
lavage
lavages

Software Mentioned

Sigmastat
SPSS

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