Particulate matter, the newborn methylome, and cardio-respiratory health outcomes in childhood

Environmental Epigenetics
Carrie V BretonFrank D Gilliland

Abstract

Ambient air pollution is associated with adverse health outcomes including cardio-respiratory diseases. Epigenetic mechanisms such as DNA methylation may play a role in driving such associations. We investigated the effects of prenatal particulate matter (PM) exposure on DNA methylation of 178,309 promoter regions in 240 newborns using the Infinium HumanMethylation450 BeadChip, using a generalized linear regression model with a quasi-binomial link family, adjusted for gender, plate, and cell types. PM-associated CpG loci were then investigated for their associations with childhood asthma, carotid intima-media thickness (CIMT), and blood pressure (BP) using logistic or linear regression. Thirty-one loci were associated with either PM10 or PM2.5 using FDR-corrected p-values of less than 0.15. Two loci were evaluated for replication in a separate population of 280 Children's Health Study (CHS) subjects using Pyrosequencing, of which one successfully replicated (COLEC11 cg03579365). Three of the 31 loci were also associated with physician-diagnosed asthma at 6 years old, two were associated with CIMT and one with systolic BP at 10 years old. A higher methylation level in TM9SF2 (cg02015529) and UBE2S (cg00035623), respectively, was...Continue Reading

References

Jul 1, 1990·Statistics in Medicine·Y Hochberg, Y Benjamini
Mar 2, 1999·American Journal of Respiratory and Critical Care Medicine·J M PetersD C Thomas
Mar 2, 1999·American Journal of Respiratory and Critical Care Medicine·J M PetersD C Thomas
Mar 29, 2000·Theriogenology·D J Barker
Dec 4, 2001·Annals of Internal Medicine·H N HodisUNKNOWN Estrogen in the Prevention of Atherosclerosis Trial Research Group
Nov 9, 2002·Bioinformatics·Long-Cheng Li, Rajvir Dahiya
May 6, 2006·Environmental Health Perspectives·Rob McConnellJohn Peters
Sep 18, 2008·Journal of Cell Science·Evelyne BergeretMarie-Odile Fauvarque
Mar 5, 2009·American Journal of Epidemiology·Matthew J StricklandPaige E Tolbert
Mar 10, 2009·Environmental Health Perspectives·Letizia TarantiniAndrea Baccarelli
Aug 11, 2009·Current Opinion in Pediatrics·Molini M Patel, Rachel L Miller
Oct 27, 2009·Inhalation Toxicology·Nilsa Regina Damaceno-RodriguesElia Garcia Caldini
Dec 2, 2009·Circulation·Michael McGeachieMarco F Ramoni
Apr 20, 2010·Cancer Cell·Houtan NoushmehrUNKNOWN Cancer Genome Atlas Research Network
Dec 15, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lindsay Wichers StanekDaniel L Costa
Jun 1, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·F J Kelly, J C Fussell
Jun 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Takashi TanakaShinichiro Chuma
Oct 22, 2011·The Korean Journal of Internal Medicine·Hajime Takizawa
Nov 25, 2011·Thrombosis Research·Massimo Franchini, Pier Mannuccio Mannucci
Mar 27, 2012·Journal of Cardiovascular Translational Research·Julio A Chirinos
May 10, 2012·BMC Bioinformatics·Eugene Andres HousemanKarl T Kelsey
May 18, 2012·Environmental Health Perspectives·Carrie V BretonFrank D Gilliland
Nov 24, 2012·Current Pharmaceutical Design·Elisabetta BianchiniLorenzo Ghiadoni
Mar 12, 2013·Nucleic Acids Research·Timothy J TricheKimberly D Siegmund
Jun 8, 2013·Particle and Fibre Toxicology·Bram G JanssenTim S Nawrot
Nov 5, 2013·International Journal of Hygiene and Environmental Health·Chuang LiuUNKNOWN GINIplus and LISAplus Study Groups
Jan 18, 2014·Environmental and Molecular Mutagenesis·Liqiong GuoAndrea A Baccarelli
Feb 4, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Weiliang XieJohn F Engelhardt
Mar 4, 2014·Physiology·Suttira IntapadBarbara T Alexander
Mar 13, 2014·Current Problems in Pediatric and Adolescent Health Care·Roya Kelishadi, Parinaz Poursafa

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Citations

Aug 14, 2018·Journal of Developmental Origins of Health and Disease·J F Felix, C A M Cecil
Oct 27, 2018·Current Environmental Health Reports·Rossella AlfanoMichelle Plusquin
Jun 1, 2019·Environmental Health Perspectives·Olena GruzievaErik Melén
Feb 20, 2020·International Journal of Environmental Research and Public Health·Hannah Lui Park
Jul 2, 2019·Environmental Research·Sergi Sayols-BaixerasRoberto Elosua
Apr 23, 2021·Cardiovascular Toxicology·Noor Ul Ain, Safi Ur Rehman Qamar
Oct 31, 2020·Environmental Science & Technology·Jessica E LainePaolo Vineis
Sep 10, 2021·Environmental Science and Pollution Research International·Suranjana MukherjeeKoel Chaudhury
Oct 17, 2021·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Qinglin SunJunchao Duan

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Methods Mentioned

BETA
protein collection
PCR

Software Mentioned

TeleAtlas
methylumi
R
Pyrosequencing
MethPrimer

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