Partitioned exhaled nitric oxide to non-invasively assess asthma.

Respiratory Physiology & Neurobiology
James L Puckett, Steven C George

Abstract

Asthma is a chronic inflammatory disease of the lungs, characterized by airway hyperresponsiveness. Chronic repetitive bouts of acute inflammation lead to airway wall remodeling and possibly the sequelae of fixed airflow obstruction. Nitric oxide (NO) is a reactive molecule synthesized by NO synthases (NOS). NOS are expressed by cells within the airway wall and functionally, two NOS isoforms exist: constitutive and inducible. In asthma, the inducible isoform is over expressed, leading to increased production of NO, which diffuses into the airway lumen, where it can be detected in the exhaled breath. The exhaled NO signal can be partitioned into airway and alveolar components by measuring exhaled NO at multiple flows and applying mathematical models of pulmonary NO dynamics. The airway NO flux and alveolar NO concentration can be elevated in adults and children with asthma and have been correlated with markers of airway inflammation and airflow obstruction in cross-sectional studies. Longitudinal studies which specifically address the clinical potential of partitioning exhaled NO for diagnosis, managing therapy, and predicting exacerbation are needed.

References

Dec 16, 1991·Biochemical and Biophysical Research Communications·L E GustafssonS Moncada
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·L N HeissW E Goldman
Feb 1, 1994·American Journal of Respiratory and Critical Care Medicine·B GastonJ S Stamler
Aug 30, 1994·Biochemical and Biophysical Research Communications·R A RobbinsJ M Polak
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·K AsanoJ S Stamler
Apr 1, 1995·Nature Medicine·J O LundbergK Alving
Aug 1, 1995·American Journal of Respiratory and Critical Care Medicine·A F MassaroJ M Drazen
Jun 1, 1995·American Journal of Respiratory and Critical Care Medicine·S A KharitonovP J Barnes
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·S A KharitonovP J Barnes
Feb 1, 1996·American Journal of Respiratory and Critical Care Medicine·B KimberlyW E Holden
May 1, 1996·American Journal of Respiratory and Critical Care Medicine·G Sadeghi-HashjinF P Nijkamp
Jun 1, 1996·American Journal of Respiratory and Critical Care Medicine·S A KharitonovP J Barnes
Feb 1, 1996·The European Respiratory Journal·S A KharitonovP J Barnes
Mar 1, 1996·Thorax·P J Barnes, S A Kharitonov
Jun 1, 1996·The European Respiratory Journal·P GarnierA T Dinh-Xuan
Jan 1, 1997·American Journal of Respiratory and Critical Care Medicine·P E SilkoffN Zamel
Mar 28, 1998·American Journal of Respiratory and Critical Care Medicine·A DeykinE Israel
Mar 28, 1998·American Journal of Respiratory and Critical Care Medicine·L J DupontG M Verleden
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·S LimP J Barnes
Mar 2, 1999·American Journal of Respiratory and Critical Care Medicine·C M SalomeA J Woolcock
Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·R LouisR Djukanović
Nov 4, 2000·Respiratory Medicine·M HögmanP Meriläinen
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·J D LeuppiA J Woolcock
Feb 24, 2001·Respiratory Medicine·A C OlinK Torén
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·L LehtimäkiE Moilanen
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·S A Kharitonov, P J Barnes
Jul 21, 2001·American Journal of Respiratory and Critical Care Medicine·S LimG Carramori
Sep 11, 2001·American Journal of Respiratory and Critical Care Medicine·A ten BrinkeE H Bel
Nov 22, 2001·The European Respiratory Journal·L LehtimäkiE Moilanen

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Citations

Jan 21, 2009·Respiratory Research·Jingjing JiangSteven C George
Apr 30, 2010·Respiratory Research·James L PuckettSteven C George
Jan 27, 2016·Nutrition Research Reviews·Aishwarya KumarMartin R Lindley
Jul 14, 2010·The Journal of Allergy and Clinical Immunology·Parameswaran NairFrederick E Hargreave
Sep 24, 2009·Pediatric Pulmonology·William S LinnFrank D Gilliland
Jan 19, 2010·Pediatric Pulmonology·James L PuckettSteven C George
Mar 27, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Toshihiro ShiraiKingo Chida
Dec 10, 2014·The Journal of Allergy and Clinical Immunology·Douglas C CowanSuzy A A Comhair
Jun 13, 2020·Journal of Breath Research·Lorenzo PetraliaGrant Ritchie
May 21, 2013·Pediatric Pulmonology·William S LinnFrank D Gilliland
Aug 17, 2010·American Journal of Respiratory and Critical Care Medicine·Thomas RitzRichard J Auchus
Sep 12, 2009·Journal of Applied Physiology·Lars L KarlssonDag Linnarsson
Jan 1, 2019·ACS Applied Materials & Interfaces·Jin WuLeslie K Norford

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