Partitioning glucose distribution/transport, disposal, and endogenous production during IVGTT

American Journal of Physiology. Endocrinology and Metabolism
Roman HovorkaRichard H Jones

Abstract

We have separated the effect of insulin on glucose distribution/transport, glucose disposal, and endogenous production (EGP) during an intravenous glucose tolerance test (IVGTT) by use of a dual-tracer dilution methodology. Six healthy lean male subjects (age 33 +/- 3 yr, body mass index 22.7 +/- 0.6 kg/m(2)) underwent a 4-h IVGTT (0.3 g/kg glucose enriched with 3-6% D-[U-(13)C]glucose and 5-10% 3-O-methyl-D-glucose) preceded by a 2-h investigation under basal conditions (5 mg/kg of D-[U-(13)C]glucose and 8 mg/kg of 3-O-methyl-D-glucose). A new model described the kinetics of the two glucose tracers and native glucose with the use of a two-compartment structure for glucose and a one-compartment structure for insulin effects. Insulin sensitivities of distribution/transport, disposal, and EGP were similar (11.5 +/- 3.8 vs. 10.4 +/- 3.9 vs. 11.1 +/- 2.7 x 10(-2) ml small middle dot kg(-1) small middle dot min(-1) per mU/l; P = nonsignificant, ANOVA). When expressed in terms of ability to lower glucose concentration, stimulation of disposal and stimulation of distribution/transport accounted each independently for 25 and 30%, respectively, of the overall effect. Suppression of EGP was more effective (P < 0.01, ANOVA) and accounted ...Continue Reading

References

Sep 1, 1992·The American Journal of Physiology·J RosenblattR R Wolfe
Oct 1, 1990·Physiological Reviews·A Carruthers
Aug 1, 1989·Diabetes/metabolism Reviews·R N BergmanM Ader
Sep 1, 1989·The American Journal of Physiology·B KalderonA Lapidot
Jan 1, 1985·Endocrine Reviews·R N BergmanM Ader
Jul 1, 1985·The Journal of Clinical Investigation·E FerranniniR A DeFronzo
Oct 1, 1984·The Journal of Clinical Investigation·G I ShulmanR G Shulman
Apr 1, 1995·The American Journal of Physiology·J H YounG M Steil
Mar 1, 1995·The American Journal of Physiology·M J ChristopherF P Alford
Dec 1, 1994·The Journal of Clinical Investigation·A A AlzaidR A Rizza
Aug 1, 1994·The American Journal of Physiology·A D Baron
Oct 1, 1993·Baillière's Clinical Endocrinology and Metabolism·R C BonadonnaC Cobelli
Jul 1, 1993·The Journal of Clinical Investigation·R C BonadonnaR A DeFronzo
Apr 17, 1998·Diabetic Medicine : a Journal of the British Diabetic Association·R HovorkaM A Young
Jun 11, 1999·The American Journal of Physiology·A CaumoC Cobelli
Apr 26, 2000·American Journal of Physiology. Endocrinology and Metabolism·A NataliA Mari
Feb 24, 2001·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·R N BergmanM Ellmerer
Dec 1, 1962·Annals of Internal Medicine·J S FORDTRANF J INGELFINGER

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Citations

Apr 7, 2009·Diabetes Technology & Therapeutics·Meriyan Eren-OrukluDonald Smith
Jul 27, 2010·Medical & Biological Engineering & Computing·Amjad Abu-RmilehDarine Zambrano
Dec 1, 2010·Medical & Biological Engineering & Computing·Federico GalvaninFabrizio Bezzo
Apr 3, 2014·Journal of Healthcare Engineering·Kamuran Turksoy, Ali Cinar
May 9, 2012·Computer Methods and Programs in Biomedicine·Amjad Abu-Rmileh, Winston Garcia-Gabin
Dec 20, 2011·Computer Methods and Programs in Biomedicine·J Fernandez de CaneteJ C Ramos-Diaz
Sep 23, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M TrombettaR C Bonadonna
Sep 28, 2010·Computer Methods and Programs in Biomedicine·M García-JaramilloJ Vehí
Jul 6, 2010·Mathematical Biosciences·C E HannG M Shaw
May 1, 2010·Computer Methods and Programs in Biomedicine·Amjad Abu-Rmileh, Winston Garcia-Gabin
Jan 13, 2015·Computer Methods and Programs in Biomedicine·Alain BockDenis Gillet
May 12, 2009·Molecular and Cellular Endocrinology·Yin Hoon ChewRamlan Abdul Aziz
Feb 5, 2009·Journal of Process Control·Gianni MarchettiDale E Seborg
Dec 20, 2007·The Journal of Pharmacy and Pharmacology·Terry G FarmerNicholas A Peppas
Mar 26, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·N S OliverD G Johnston
Jul 19, 2013·IEEE Transactions on Bio-medical Engineering·Ahmad HaidarRoman Hovorka
Jan 24, 2015·IEEE Transactions on Bio-medical Engineering·Nicolas MagdelaineEric Le Carpentier
Jul 18, 2008·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Enrique J GómezAlberto de Leiva
Dec 13, 2012·IEEE Transactions on Bio-medical Engineering·Paul D DochertyJ Geoffrey Chase
Nov 4, 2009·IEEE Transactions on Bio-medical Engineering·Aaron J Le CompteGeoffrey M Shaw
Nov 13, 2004·Metabolism: Clinical and Experimental·Malgorzata E WilinskaRoman Hovorka
Dec 18, 2004·Medical Engineering & Physics·J Geoffrey ChaseBob Broughton
Mar 13, 2008·IEEE Transactions on Bio-medical Engineering·Gianni MarchettiDale E Seborg
Nov 9, 2004·Artificial Intelligence in Medicine·Ludovic J ChassinRoman Hovorka
Jan 1, 2009·IEEE Reviews in Biomedical Engineering·Claudio CobelliBoris P Kovatchev
Jun 19, 2015·IEEE Journal of Biomedical and Health Informatics·Kamuran TurksoyAli Cinar
Mar 23, 2012·Computer Methods and Programs in Biomedicine·Federico GalvaninFabrizio Bezzo
Mar 1, 2012·Computer Methods and Programs in Biomedicine·Ahmad HaidarRoman Hovorka
Jun 30, 2012·Computer Methods and Programs in Biomedicine·Diego de PeredaJorge Bondia
Nov 5, 2013·Computer Methods and Programs in Biomedicine·P Colmegna, R S Sánchez Peña
Nov 1, 2008·Journal of Drug Delivery Science and Technology·T G FarmerN A Peppas
Jul 25, 2008·Diabetes Care·Mary E PennantDavid B Dunger
May 9, 2016·Medical & Biological Engineering & Computing·Fernando García-GarcíaM Elena Hernando
Aug 31, 2016·Domestic Animal Endocrinology·M K Reeve-JohnsonD Vankan
Oct 6, 2010·Journal of Diabetes Science and Technology·Matthew W PercivalFrancis J Doyle

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