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Partitioning heritability by functional category using GWAS summary statistics

bioRxiv

Jan 23, 2015

Hilary Kiyo FinucaneAlkes L. Price

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Abstract

Recent work has demonstrated that some functional categories of the genome contribute disproportionately to the heritability of complex diseases. Here, we analyze a broad set of functional elements, including cell-type-specific elements, to estimate their polygenic contributions to heri...read more

Mentioned in this Paper

Menarche
Genome
Genome-Wide Association Study
EAF2 gene
Phenotype Determination
Follow-up
Activated Lymphocyte
Body Mass Index Procedure
Body Mass Index
Immune System Diseases
17
1
145
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  • Partitioning heritability by functional category using GWAS summary statistics

    bioRxiv

    Jan 23, 2015

    Hilary Kiyo FinucaneAlkes L. Price

    PMID: 990014241

    DOI: 10.1101/014241

    Abstract

    Recent work has demonstrated that some functional categories of the genome contribute disproportionately to the heritability of complex diseases. Here, we analyze a broad set of functional elements, including cell-type-specific elements, to estimate their polygenic contributions to heri...read more

    Mentioned in this Paper

    Menarche
    Genome
    Genome-Wide Association Study
    EAF2 gene
    Phenotype Determination
    17
    1
    145

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