journal cover

Partitioning heritability by functional annotation using genome-wide association summary statistics

Nature Genetics

Sep 29, 2015

Hilary FinucaneAlkes L Price

Abstract

Recent work has demonstrated that some functional categories of the genome contribute disproportionately to the heritability of complex diseases. Here we analyze a broad set of functional elements, including cell type-specific elements, to estimate their polygenic contributions to herit...read more

Mentioned in this Paper

Histone H7
EAF2 gene
Immune System Diseases
Menarche
Methylation
Genetic Predisposition to Disease
Genome-Wide Association Study
Biological Markers
In Silico
Body Mass Index Procedure
83
760
1
Paper Details
References
  • References47
  • Citations167
12345
  • References47
  • Citations167
12345...

Partitioning heritability by functional annotation using genome-wide association summary statistics

Nature Genetics

Sep 29, 2015

Hilary FinucaneAlkes L Price

PMID: 26414678

DOI: 10.1038/ng.3404

Abstract

Recent work has demonstrated that some functional categories of the genome contribute disproportionately to the heritability of complex diseases. Here we analyze a broad set of functional elements, including cell type-specific elements, to estimate their polygenic contributions to herit...read more

Mentioned in this Paper

Histone H7
EAF2 gene
Immune System Diseases
Menarche
Methylation
Genetic Predisposition to Disease
Genome-Wide Association Study
Biological Markers
In Silico
Body Mass Index Procedure
83
760
1

Related Papers

Paper Details
References
  • References47
  • Citations167
12345
  • References47
  • Citations167
12345...
/papers/partitioning-heritability-by-functional/26414678