Partitioning of an anchor dipeptide in a phospholipid membrane

The Journal of Physical Chemistry. B
V V Volkov, R Righini

Abstract

We explore the localization of a guest N-myristoylated methyl glycine anchor dipeptide in a phospholipid environment. The dipeptide is part of a conservative sequence, which ensures proper association of a wide group of proteins in living organisms with a cellular phospholipid membrane. Using linear and two-color anharmonic infrared spectroscopy, we measure relative degrees of hydration of the amide I modes of the dipeptide and of phospholipid carbonyls. The atomic density of water in dependence of the distance from the hydrophobic center of the bilayer (a result of an independent Neutron scattering experiment) allows us to determine the relative altitudes of the peptide carbonyls with respect to those of the phospholipid ones. Considering this, and the dimensions of the dipeptide molecular frame, we anticipate the average angle between the backbone of the dipeptide and the normal to the membrane surface. The results provide a descriptive picture of the depth and geometry of partitioning of a guest N-myristoylated methyl glycine anchor dipeptide into a phospholipid membrane.

References

Jul 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·M C AsplundR M Hochstrasser
Aug 31, 2001·The Journal of Biological Chemistry·T A FaraziJ I Gordon
Apr 1, 2005·Nature·Tobias BrixnerGraham R Fleming
Apr 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Gonzalo L VilasLuc G Berthiaume
Jul 20, 2006·Journal of the American Chemical Society·Victor V VolkovRoberto Righini
Jul 21, 2006·The Journal of Physical Chemistry. B·Alex H de VriesPhilippe H Hünenberger
Jan 26, 2007·The Journal of Physical Chemistry. B·Victor V VolkovRoberto Righini
Sep 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·V V VolkovR Righini
Oct 13, 2007·Physical Review Letters·Victor V VolkovRoberto Righini
Mar 19, 2008·The Journal of Chemical Physics·Sean Garrett-Roe, Peter Hamm
Feb 21, 2009·The Journal of Physical Chemistry. B·Victor V VolkovRoberto Righini

❮ Previous
Next ❯

Citations

Mar 30, 2011·The Journal of Physical Chemistry. B·Victor V VolkovRoberto Righini

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.