PARV4 prevalence, phylogeny, immunology and coinfection with HIV, HBV and HCV in a multicentre African cohort.

Wellcome Open Research
Colin SharpPhilippa C Matthews

Abstract

Background: The seroprevalence of human parvovirus-4 (PARV4) varies considerably by region. In sub-Saharan Africa, seroprevalence is high in the general population, but little is known about the transmission routes or the prevalence of coinfection with blood-borne viruses, HBV, HCV and HIV.  Methods: To further explore the characteristics of PARV4 in this setting, with a particular focus on the prevalence and significance of coinfection, we screened a cohort of 695 individuals recruited from Durban and Kimberley (South Africa) and Gaborone (Botswana) for PARV4 IgG and DNA, as well as documenting HIV, HBV and HCV status.  Results: Within these cohorts, 69% of subjects were HIV-positive. We identified no cases of HCV by PCR, but 7.4% were positive for HBsAg. PARV4 IgG was positive in 42%; seroprevalence was higher in adults (69%) compared to children (21%) (p<0.0001) and in HIV-positive (52%) compared to HIV-negative individuals (24%) (p<0.0001), but there was no association with HBsAg status. We developed an on-line tool to allow visualization of coinfection data (https://purl.oclc.org/coinfection-viz). We identified five subjects who were PCR-positive for PARV4 genotype-3. Ex vivo CD8+ T cell responses spanned the entire PARV4 ...Continue Reading

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Citations

Sep 19, 2019·Transboundary and Emerging Diseases·Andrea ChavesGustavo A Gutiérrez-Espeleta
Jul 10, 2019·Annual Review of Virology·Maria Söderlund-Venermo
Oct 22, 2018·Archives of Virology·Kristýna BrožováKristýna Hrazdilová

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Datasets Mentioned

BETA
KU871314
KU871315
KX681684
KX681685

Methods Mentioned

BETA
flow cytometry
PCR
amplicon sequencing

Software Mentioned

MEGA
highcharter
GraphPad
SSE

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