Parvalbumin and calbindin D-28K immunoreactive neurons in area MT of rhesus monkey

Experimental Brain Research
P DharK Sharma

Abstract

The chemical characteristics of the neurons of the motion sensitive visual area, area MT, remain to be established. We studied the distribution pattern of two calcium binding proteins, parvalbumin (PV) and calbindin D28K (CB) in this area, using specific monoclonal antibodies and the peroxidase-antiperoxidase (PAP) immunohistochemical technique. Aldehyde fixed 30-micron-thick cryostat sections from area MT of five animals were processed free floating for immunohistochemical staining. Besides studying the morphological characteristics of PV and CB positive neurons, quantitative analysis was carried out to determine their (1) perikaryal area (Pa) and diameter, (2) numerical densities (NV)/mm3 cortical tissue, (3) absolute number (NC) in a column of cortex under 1 mm2 cortical surface along with (4) layerwise absolute number (NL) under 1 mm2 cortical surface and (5) laminar percentage distribution of immunoreactive (IR) neurons. Quantitative analysis was carried out using a Leica QMC 500 image analysis system connected to a DMRE microscope. The results showed that both types of IR neurons were localized to all cortical layers except layer I. The PV +ve neurons were equidistributed between the supra- and infragranular layers, with ...Continue Reading

Citations

Jan 27, 2005·Experimental Brain Research·Sébastien DesgentMaurice Ptito
Nov 18, 2008·Brain Structure & Function·Chet C SherwoodPatrick R Hof
Nov 29, 2012·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Jaikishan JayakumarTrichur R Vidyasagar
May 14, 2016·Cerebral Cortex·Selina S SolomonSamuel G Solomon
Nov 17, 2006·Journal of Neurophysiology·Leo L LuiMarcello G P Rosa

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