Parvalbumin expression in the claustrum of the adult dog. An immunohistochemical and topographical study with comparative notes on the structure of the nucleus

Journal of Chemical Neuroanatomy
Andrea PironeArti Ahluwalia

Abstract

Although the detailed structure and function of the claustrum remain enigmatic, its extensive reciprocal connection with the cortex suggests a role in the integration of multisensory information. Claustrum samples, obtained from necropsy of four dogs, were formalin fixed for paraffin embedding. Sections were either stained for morpho-histological analysis or immunostained for parvalbumin (PV). We focused on PV because in cortical and hippocampal areas it is a marker of the fast-spiking interneurons which have an important role in the information transmission and processing. Soma area, perimeter and circularity were considered as morphological parameters to quantitatively group the PV positive somata by k-means clustering. The histological investigation revealed a superior pyramidoid puddle and a posterior puddle characterized by a "cloud" of neurons in its dorso-lateral part. Immunostaining showed positive somata and fibers throughout the rostro-caudal extent of the dog claustrum, localized principally in the dorsal region. k-Means clustering analysis enabled neuron classification according to size, identifying respectively big (radius=11.42±1.99μm) and small (radius=6.33±1.08μm) cells. No statistical differences in soma shape ...Continue Reading

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Citations

Oct 3, 2017·Journal of Anatomy·Andrea PironeBruno Cozzi
Feb 8, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Andrea PironeAlberto Granato
Sep 12, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Joan S BaizerJames F Baker
Oct 12, 2018·Journal of Molecular Histology·Dimka Hinova-PalovaAdrian Paloff
Jun 20, 2019·Frontiers in Neuroanatomy·Christopher M DillinghamShane M O'Mara
Aug 16, 2018·Brain Structure & Function·Michael G White, Brian N Mathur
Jul 16, 2019·Journal of Molecular Histology·Dimka Hinova-PalovaAdrian Paloff
Sep 5, 2020·Journal of Anatomy·Andrea PironeBruno Cozzi

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