Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory

Nature Neuroscience
Andrew J MurrayPeer Wulff


Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory.


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