Parvalbumin-positive interneurons of the prefrontal cortex support working memory and cognitive flexibility

Scientific Reports
Andrew J MurrayPeer Wulff


Dysfunction of parvalbumin (PV)-positive GABAergic interneurons (PVIs) within the prefrontal cortex (PFC) has been implicated in schizophrenia pathology. It is however unclear, how impaired signaling of these neurons may contribute to PFC dysfunction. To identify how PVIs contribute to PFC-dependent behaviors we inactivated PVIs in the PFC in mice using region- and cell-type-selective expression of tetanus toxin light chain (TeLC) and compared the functional consequences of this manipulation with non-cell-type-selective perturbations of the same circuitry. By sampling for behavioral alterations that map onto distinct symptom categories in schizophrenia, we show that dysfunction of PVI signaling in the PFC specifically produces deficits in the cognitive domain, but does not give rise to PFC-dependent correlates of negative or positive symptoms. Our results suggest that distinct aspects of the complex symptomatology of PFC dysfunction in schizophrenia can be attributed to specific prefrontal circuit elements.


Dec 1, 1992·Archives of General Psychiatry·A WolkinJ Rotrosen
Jan 1, 1987·Psychopharmacology·J A LiebermanJ Alvir
Feb 1, 1983·Experimental Neurology·H EichenbaumA Feeley
Oct 29, 1996·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D R Weinberger, Karen Faith Berman
Apr 11, 1997·Schizophrenia Research·C L Beasley, G P Reynolds
Jan 29, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A BertolinoD R Weinberger
Feb 28, 2002·Nature Neuroscience·Andreas Meyer-LindenbergKaren Faith Berman
Jun 6, 2002·Behavioural Brain Research·Laurent LacroixJoram Feldon
Jan 16, 2003·Physiology & Behavior·Susan R Sesack, David B Carr
Mar 19, 2003·Behavioural Brain Research·Robert M J DeaconJ Nicholas P Rawlins
Nov 15, 2003·Cerebral Cortex·Marc W HowardMichael J Kahana
Dec 4, 2003·Behavioural Brain Research·Harry B M UylingsBryan Kolb
Dec 4, 2003·Behavioural Brain Research·Kerry McAlonan, Verity J Brown
Sep 21, 2004·Nature Reviews. Neuroscience·Henry MarkramCaizhi Wu
Jan 22, 2005·Current Opinion in Pharmacology·Brian J MorrisJudith A Pratt
Apr 2, 2005·Nature Reviews. Neuroscience·David A LewisDavid W Volk
Aug 13, 2005·Neuroscience and Biobehavioral Reviews·Andrew HolmesCatherine Belzung
Nov 11, 2005·PLoS Biology·Matthew W Jones, Matthew A Wilson
Oct 4, 2006·Neuron·P Alexander Arguello, Joseph A Gogos
Aug 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Takatoshi HikidaAkira Sawa
Oct 24, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sanbing ShenDavid St Clair
Feb 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Peer WulffHannah Monyer
Feb 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel J LodgeAnthony A Grace
Apr 28, 2009·Nature·Vikaas S SohalKarl Deisseroth
May 5, 2009·Trends in Neurosciences·Christoph KellendonkEric R Kandel
Jun 17, 2009·Behavioural Brain Research·Gernot RiedelB Platt
Nov 26, 2009·Schizophrenia Bulletin·Colm M P O'TuathaighJohn L Waddington
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Lei WenLin Mei
Feb 20, 2010·Current Opinion in Neurobiology·Angie A KehagiaTrevor W Robbins
Feb 25, 2010·Current Biology : CB·Alan Baddeley
Mar 31, 2010·Annual Review of Neuroscience·Chad E Forbes, Jordan Grafman
Sep 30, 2010·Nature Neuroscience·Eric J Nestler, Steven E Hyman
Dec 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Herbert E CovingtonEric J Nestler
Dec 14, 2011·Trends in Neurosciences·David A LewisDavid W Volk
Dec 16, 2011·Trends in Cognitive Sciences·Deanna M Barch, Alan Ceaser
Jan 19, 2012·Nature Reviews. Neuroscience·Oscar Marín
Oct 19, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Simon HanslmayrKarl-Heinz T Bäuml


Mar 8, 2016·Neurobiology of Disease·David J KossBettina Platt
Dec 8, 2016·Neuroscience·Hiroshi UenoTakeshi Ishihara
May 14, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Adriana CaballeroKuei Y Tseng
Aug 21, 2020·Physiological Reviews·Jochen F Staiger, Carl C H Petersen
Aug 31, 2020·Neurologia Medico-chirurgica·Isamu MiuraToru Takumi
Apr 20, 2018·Scientific Reports·Chelsea S SullivanPatricia F Maness
Feb 28, 2018·Frontiers in Neural Circuits·Adrienne MuellerTirin Moore
Jun 28, 2019·Frontiers in Human Neuroscience·Geon Ha KimSujung Yoon
Nov 20, 2019·The Journal of Clinical Investigation·Danielle M GerhardRonald S Duman
Oct 9, 2018·Cerebral Cortex·Jivan KhlghatyanJean-Martin Beaulieu
Jul 31, 2019·Proceedings of the National Academy of Sciences of the United States of America·Xiaofei DengJing Liang
Jul 24, 2019·Frontiers in Molecular Neuroscience·Olivia K Swanson, Arianna Maffei
Sep 12, 2018·Particle and Fibre Toxicology·Masakazu UmezawaKarin S Hougaard

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