Parvovirus B19 infection in children with acute lymphoblastic leukemia is associated with cytopenia resulting in prolonged interruptions of chemotherapy

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Anna LindblomK Broliden

Abstract

Parvovirus B19 infection causes severe cytopenia and can mimic a leukemic relapse or therapy-induced cytopenia in patients with hematologic malignancies. We evaluated the complications of parvovirus B19 infection, including delays in the scheduled course of chemotherapy, in children with acute lymphoblastic leukemia (ALL). Consecutive bone marrow samples were collected from 117 children with ALL and were analyzed for parvovirus B19 DNA by polymerase chain reaction. Clinical and laboratory data were collected from the Nordic Childhood Leukemia Registry and from medical records. Among the 117 children with ALL, 18 (15%) were found to be parvovirus B19 DNA positive. The infection was suspected on clinical grounds in only 1 of these 18 patients. Patients with viremia at diagnosis or during therapy for infection had lower viral loads (median viral load, 7 x 10(4) copies/mL) than did those who became viremic during maintenance therapy (median viral load, 2 x 10(8) copies/mL). The former group also had fewer clinical complications. Indeed, when parvovirus B19 DNA was present during the maintenance treatment, the number of complications (including cytopenia) increased, causing significantly longer periods without chemotherapy (median d...Continue Reading

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Citations

Jan 16, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Angel C Bassols
Apr 20, 2011·The Pediatric Infectious Disease Journal·Herwig LacknerChristian Urban
Mar 6, 2009·Journal of Pediatric Hematology/oncology·Othman El-Sayed SolimanBothina Kora
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Jan 1, 2011·Case Reports in Transplantation·Panagiotis TsirigotisJohn Dervenoulas
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Jan 9, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Anna LindblomThomas Tolfvenstam
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Sep 13, 2020·Pediatric Blood & Cancer·Constanze Buus-GehrigThomas Lehrnbecher
Jul 31, 2018·Pediatric Blood & Cancer·Subramaniam RamanathanShripad Banavali
Oct 9, 2020·Case Reports in Pediatrics·Pratik A PatelDaniel S Wechsler

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