Parvovirus B19 infection in pregnancy-awareness and opportunities

Current Opinion in Virology
Francesca BonviciniGiorgio Gallinella

Abstract

Parvovirus B19 (B19V) is a human pathogenic virus associated with a wide range of clinical conditions. In pregnancy, B19V poses a potential hazard to the fetus as crossing the placental barrier and infecting erythroid progenitor cells in bone marrow and liver, it blocks fetal erythropoiesis leading to profound anemia, hydrops and/or fetal death. The virus is not regarded as a teratogen, however more scientific awareness is emerging on mechanisms and consequences of intrauterine infection and possible sequelae in the neonatal development. Reliable diagnostic procedures and fetal management strategies, including intrauterine transfusion, are established. In spite of being a recognized fetotropic agent possibly leading to fetal loss, testing for B19V is not routinely included in preconception or antenatal screenings, possibly delaying the management of B19V-complicated pregnancies. Continuous advances in B19V research will provide for better diagnostic methods and algorithms, as well as for the development of effective prophylactic interventions and novel therapeutic options.

Citations

Jul 22, 2018·Expert Review of Molecular Diagnostics·Giorgio Gallinella
Jul 27, 2018·Annual Review of Virology·Lenore Pereira
Mar 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ilaria ContiAlberto Leoni
Sep 12, 2019·Revista Da Sociedade Brasileira De Medicina Tropical·Regina Maria Pinto de FigueiredoFelipe Gomes Naveca
Jul 22, 2019·Viruses·Elisabetta Manaresi, Giorgio Gallinella
Jul 26, 2018·International Journal of Molecular Sciences·Luciano Amarelle, Emilia Lecuona
Jul 5, 2018·Medical Microbiology and Immunology·Annemarie Berger, Hans Wilhelm Doerr
Jan 14, 2021·Future Microbiology·Rita de Cnc Garcia, Luciane Aa Leon
Apr 4, 2021·International Journal of Molecular Sciences·Kavita NarangRegan N Theiler

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