Parvovirus vectors: use and optimisation in cancer gene therapy

Expert Reviews in Molecular Medicine
Boris Blechacz, Stephen J Russell

Abstract

With the increasing incidence and mortality of cancer worldwide, there is an urgent need for new therapeutic approaches. Gene therapy is one such approach and preliminary data are promising. Viral and nonviral vector systems for gene delivery are available, but most of the current systems suffer from disadvantages such as low transfection efficiencies, in vivo instability, targeting problems, mutagenic potential and immunogenicity. Viruses of the Parvoviridae family, which are characterised by their oncotropism, oncosuppression, long-term gene expression and human apathogenicity, potentially offer advantages as viral vectors. This article evaluates their usefulness in gene therapy strategies for cancer.

Citations

Jan 19, 2008·Cancer Gene Therapy·L KrügerJ A Kleinschmidt
Nov 30, 2012·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Sujata HalderMavis Agbandje-McKenna
Jul 29, 2011·Journal of Virology·Huiquan LiuDaohong Jiang
Mar 2, 2013·Journal of Virology·Sujata HalderMavis Agbandje-McKenna
Dec 13, 2006·Journal of Nanobiotechnology·Leona GilbertChristian Oker-Blom
May 3, 2011·Polish Journal of Veterinary Sciences·A Valdovska, M Pilmane
Jul 23, 2014·Current Opinion in Virology·Lin-Ya HuangMavis Agbandje-McKenna

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Cell-Type-Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Cell-Type Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Cell-Type-Specific Viral Vectors (ASM)

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.