PAS-1, a protein affinity purified from Ascaris suum worms, maintains the ability to modulate the immune response to a bystander antigen

Immunology and Cell Biology
Telma M OshiroM F Macedo-Soares

Abstract

Helminth infections and parasite components have potent immunomodulatory effects on a host's immune system. In the present study, we investigated the effect of PAS-1, a protein component of Ascaris suum adult worms recognized by a monoclonal antibody (MAIP-1), on humoral and cell-mediated responses to a bystander antigen (ovalbumin [OVA]). MAIP-1 recognized only one of the three polypeptide chains of PAS-1, but neutralized the suppressive effect of the whole worm extract on OVA-specific antibody production. PAS-1 inhibited antibody production against a T-cell-dependent, but not a T-cell-independent, antigen in a dose-dependent way. IgM, IgG1, IgG2b, and also IgE and anaphylactic IgG1 levels were downregulated. In addition, PAS-1 inhibited OVA-specific delayed type hypersensitivity reactions in the footpad of mice, showing a potent immunosuppressive activity on both Th1 and Th2 responses that seems to be mediated by the induction of large amounts of IL-10 and IL-4. Indeed, PAS-1-specific spleen cells secreted sevenfold more IL-10 and threefold more IL-4 than OVA-specific cells in response to in vitro restimulation with the respective antigens. In conclusion, we showed that PAS-1, a single protein component from A. suum, maintain...Continue Reading

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Citations

May 17, 2007·Current Allergy and Asthma Reports·Maria Fernanda de Macedo Soares, Mahasti Sahihi de Macedo
Jun 22, 2014·Parasitology Research·Wheverton C NascimentoValdênia O Souza
Nov 4, 2010·Scandinavian Journal of Immunology·C A A de AraújoM F Macedo-Soares
May 17, 2019·Journal of Helminthology·S Gomez-FuentesL Adalid-Peralta
Oct 13, 2020·Frontiers in Immunology·Marie Wiedemann, David Voehringer

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