PMID: 6163310Aug 1, 1980Paper

PAS-positive polymorphonuclear leucocytes in corneal ulcers

Acta Ophthalmologica
J U Prause, O A Jensen

Abstract

Fifty consecutive cases of severe keratitis with clinical signs of corneal ulcers were examined histologically for stage of inflammatory reaction. Further, 14 similar cases were studied ultrastructurally. Cell counts of polymorphonuclears (PML), eosinophils, lymphocytes and plasma cells were carried out. Further the corneas were grouped according to their content of PAS-positive PML. The state of ulceration was estimated microscopically. PML at a cell count of greater than 10 cells/mean field (x 1000) were found in 32/50 cases, and were significantly more frequent in corneal areas with epithelial or Descemet membrane defects. Most PML were PAS-positive (26/50), the positive material having characteristics of glycogen. PAS-negative PML were found in corneas with increased amount of plasma cells. By TEM the PML were found highly phagocytic, partly degranulated and with reduced glycogen content. TEM could not, on the formalin fixed specimens, determine whether PAS-negative PML had a higher protein turn-over, but the findings indicate that corneal ulcers with PAS-negative PML contain a high amount of proteases, because of many degranulated PML and probably a reactivation of PML. Therefore the PAS stainability can be used as an indi...Continue Reading

References

Aug 1, 1979·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R T ParmleyS S Spicer
Sep 1, 1975·The British Journal of Nutrition·A PirieM C Burleigh
Oct 1, 1976·Journal of Ultrastructure Research·J J RowseyL Katona
Oct 1, 1971·The Journal of Experimental Medicine·D F BaintonM G Farquhar
Jul 1, 1965·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R D Paegle
Nov 1, 1962·Archives of Ophthalmology·R M ROBB, T KUWABARA

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.