PASADENA hyperpolarized 13C phospholactate.

Journal of the American Chemical Society
Roman V ShchepinEduard Y Chekmenev

Abstract

We demonstrate that potassium 1-(13)C-phosphoenolpyruvate becomes hyperpolarized potassium 1-(13)C-phospholactate with (13)C T(1) = 36 s after molecular hydrogenation by PASADENA (Parahydrogen and Synthesis Allows Dramatically Enhanced Nuclear Alignment). This proof-of-principle study was conducted with a fully protonated molecular precursor. (13)C was polarized to a level of 1%, corresponding to nearly 4000-fold sensitivity enhancement at 3 T. The relevant homo- and heteronuclear spin-spin couplings are reported.

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Citations

Aug 13, 2013·Journal of Magnetic Resonance·Stefan GlögglerStephan Appelt
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Jul 28, 2016·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Oleg G SalnikovEduard Y Chekmenev
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