PMID: 8952022Nov 1, 1996Paper

Passage of CD18- and CD18+ bovine neutrophils into pulmonary alveoli during acute Pasteurella haemolytica pneumonia

Veterinary Pathology
M R AckermannK A Brogden

Abstract

CD18 is a subunit for three beta 2 integrin molecules (Mac-1, p150, 95, LFA-1), which are expressed on the plasma membrane of neutrophils. These molecules mediate passage of neutrophils into sites of infection. In children and animals that lack CD18 expression, neutrophil infiltration is impaired in most tissues. However, in lung, CD18- neutrophils have been identified in the airway spaces during spontaneous episodes of pneumonia. To determine whether CD18 is vital for passage through the pulmonary alveolar wall, lung lobes of cattle with neutrophils that were deficient in CD18 expression (CD18-) and cattle with normal CD18 expression (CD18+) were inoculated with Pasteurella haemolytica by fiberoptic bronchoscopy; control lobes were inoculated with pyrogen-free saline (PFS). Neutrophil passage into alveolar lumina at 4 and 6 hours postinoculation was measured by computerized image analysis. Blood levels of neutrophils for CD18- cattle ranged from 12- to 26-fold higher than for CD18+ cattle prior to inoculation, and counts in both groups rose slightly postinoculation. In P. haemolytica-inoculated lobes, total numbers of neutrophils in alveolar lumina of the two groups were similar. An increase in the number of neutrophils in the...Continue Reading

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Citations

Jun 20, 2002·Veterinary Immunology and Immunopathology·Ernst C SoethoutVictor P M G Rutten
Sep 1, 2000·Microbes and Infection·M R Ackermann, K A Brogden
Nov 21, 2007·APMIS. Supplementum·Jørgen S Agerholm
Jan 31, 2002·Journal of Veterinary Internal Medicine·Z A RadiM R Ackermann
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·E D StolzenbergM Zasloff
Feb 5, 1998·The Journal of Veterinary Medical Science·H NagahataH Noda
Jan 13, 2005·The Journal of Veterinary Medical Science·Hajime Nagahata
Jan 9, 2001·The Veterinary Journal·B L CoomberP A Gentry
May 10, 2000·American Journal of Veterinary Research·D McClenahanD Weiss

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