PASSCLAIM--body weight regulation, insulin sensitivity and diabetes risk

European Journal of Nutrition
G RiccardiBengt Vessby

Abstract

Insulin sensitivity is a key function in human metabolism because it has a crucial role in the development of disease that are increasingly common in modern society. Impaired insulin sensitivity is an important determinant of type 2 diabetes; moreover, it has been proposed as an independent risk factor for cardiovascular disease. Thus, reduced insulin sensitivity is strongly associated with the metabolic syndrome, which represents a cluster of metabolic abnormalities and cardiovascular risk factor. Insulin sensitivity can be modulated by different environmental factors, including dietary habits. Obesity, especially if associated with abdominal adiposity, impairs insulin-sensitivity while physical activity can improve it; however, the composition of the habitual diet is clearly an important regulator of this function. To evaluate methodologies and markers that can be used to substantiate existing and potential claims of beneficial effects of foods on relevant functions connected with body fat deposition, insulin sensitivity and blood glucose regulation. We have reviewed the scientific basis for existing and potential claims, based not only on modifications of the target functions (body fat deposition, insulin sensitivity and blo...Continue Reading

Citations

Jun 4, 2005·European Journal of Nutrition·Peter J AggettHans Verhagen
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Apr 9, 2008·The British Journal of Nutrition·François MariottiJean François Huneau
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Oct 6, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Gabriele RiccardiOlga Vaccaro
Jul 3, 2004·The British Journal of Nutrition·M Parillo, G Riccardi
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